眼科新进展2017，Vol.37Issue(5)：477-479,3.DOI:10.13389/j.cnki.rao.2017.0121
抗血管内皮生长因子玻璃体内注射治疗不同区域早产儿视网膜病变的疗效观察
Efficacy of intravitreal injection of anti-vascular endothelial growth factor agent for retinopathy of prematurity in different zones
卢跃兵 1黄云云 1孙先桃 1孙爽1
作者信息
- 1. 450053 河南省郑州市,郑州儿童医院眼科
- 折叠
摘要
Abstract
Objective To observe the clinical effects of anti-vascular endothelial growth factor (VEGF) agent for retinopathy of prematurity (ROP) in different zones.Methods Retrospective analysis was performed on 24 ROP patients (46 eyes) who received intravitreal injection of anti-VEGF agent in our hospital from April 2013 to April 2014,including 15 patients (28 eyes) with Zone Ⅰ ROP and 9 patients (18 eyes) with Zone Ⅱ ROP.All the patients receive intravitreal injection of anti-VEGF agent Ranibizumab.The patients were observed for postoperative progression of fundus conditions,and the recovery rate and progression rate following initial injection were compared statistically between two groups.Results There was no statistically significant difference between the two groups in gestational age at birth or birth weight (both P ＞0.05);And statistically significant difference was found between two groups in gestational age at surgical correction (P =0.001).Following initial injection,the recovery rates were 32.14％ and 66.67％,and the progression rates were 67.86％ and 33.34％ in Zone Ⅰ ROP group and Zone Ⅱ ROP group,respectively,there was statistically significant difference between the two groups in recovery rate (x2 =5.263,P =0.022).The progression rate in Zone Ⅰ ROP group was higher than that in Zone Ⅱ ROP group,there was statistically significant difference (x2 =-2.269,P =0.023).During follow-up,no complications of intravitreal injection as cataract,endophthalmitis or retinal tears was observed;Only 2 patients experienced corneal edema,and 4 patients experienced subconjunctival hemorrhage.Conclusion Intravitreal injection of anti-VEGF agent is effective for both Zone Ⅰ and Zone Ⅱ ROP.While for Zone Ⅰ ROP,the surgery success rate is low and the reoperation rate is high,such treatment can provide favorable time and conditions for reoperation.关键词
早产儿视网膜病变/抗血管内皮生长因子药物/玻璃体内注射Key words
retinopathy of prematurity/anti-vascular endothelial growth factor/intravitreal injection分类
医药卫生引用本文复制引用
卢跃兵,黄云云,孙先桃,孙爽..抗血管内皮生长因子玻璃体内注射治疗不同区域早产儿视网膜病变的疗效观察[J].眼科新进展,2017,37(5):477-479,3.
