烟台大学学报（自然科学与工程版）2017，Vol.30Issue(2)：106-110,5.DOI:10.13951/j.cnki.37-1213/n.2017.02.005
2-芳基苯并噁唑-5-乙酰哌啶衍生物的合成及其抑菌活性
Synthesis and Antibacterial Activity of 2-(2-Phenylbenzo[d]Oxazol-5-yl)-1-(Piperidin-1-yl)Ethan-1-One Derivatives
摘要
Abstract
A sequence of reactions consisting of nitration, amidation, reduction are applied to get the key intermediate 5 by using 2-(4-hydroxyphenyl)acetic acid as raw material.After amidation between compound 5 with various aromatic acid chloride, the corresponding products go through the closed-loop reaction to obtain eight 2-(2-phenylbenzo[d]oxazol-5-yl)-1-(piperidin-1-yl)ethan-1-one derivatives catalyzed by the p-toluenesulfonic acid.The target compounds are elucidated by 1H NMR, 13C NMR and MS techniques.Antibacterial activity results show that most compounds have a certain degree of inhibitory activity against the Escherichia coli, while no obvious inhibition towards the Staphylococcus aureus.关键词
2-芳基苯并噁唑-5-乙酰哌啶/衍生物/合成/抑菌活性Key words
2-(2-phenylbenzo[d]oxazol-5-yl)-1-(piperidin-1-yl)ethan-1-one/derivative/synthesis/antibacterial activity分类
医药卫生引用本文复制引用
马宣,严宁,邵明莎,白信法,丁兆鹏,陈凌云,姚雷..2-芳基苯并噁唑-5-乙酰哌啶衍生物的合成及其抑菌活性[J].烟台大学学报（自然科学与工程版）,2017,30(2):106-110,5.基金项目
烟台大学博士基金资助项目(YX13B04) （YX13B04）
山东蓝色经济区人才发展项目(RS11YX). （RS11YX）
