烟台大学学报（自然科学与工程版）2017，Vol.30Issue(2)：124-130,7.DOI:10.13951/j.cnki.37-1213/n.2017.02.008
丹酚酸A通过抗炎抗氧化发挥对急性肾损伤大鼠的保护作用
Salvianolic Acid A Protects against Acute Kidney Injury inRats through Anti-inflammation and Antioxidation
摘要
Abstract
To study the effect of salvianolic acid A (SAA) on acute kidney injury (AKI) induced by ischemia-reperfusion (I/R) in rats, male SD rats are randomly divided into control group, sham operation group, I/R group and SAA (2.5 mg/kg, 5 mg/kg, 10 mg/kg) groups.The model of AKI in rats is made by clipping bilateral renal pedicles for 60 min, and then reperfusion for 24 hours.Twenty-four hours after reperfusion, the levels of serum creatinine (Scr), blood urea nitrogen (BUN) and renal injury factor1 (KIM-1) are determined, and morphological changes of renal tissues are also recorded.Furthermore, the serum interleukin-6 (IL-6), interleukin-10 (IL-10), malondialdehyde (MDA) concentrations, and superoxide dismutase (SOD) activity are tested.Experimental results show that treatment with SAA significantly reduces the serum levels of Scr, BUN and urine KIM-1, and alleviates the degree of tubular necrosis compared with those of the I/R group.SAA also decreases the production of IL-6 and MDA, elevates the level of IL-10, and enhances the activity of SOD.Thus, SAA can prevent AKI induced by I/R in rats, which may be related to its anti-inflammation and antioxidation features.关键词
丹酚酸A/急性肾损伤/缺血再灌注/抗炎/抗氧化Key words
salvianolic acid A/acute kidney injury/ischemia/reperfusion/anti-inflammation antioxidation分类
医药卫生引用本文复制引用
张作凯,王学凯,高振芳,田霄,杨明艳,范华英..丹酚酸A通过抗炎抗氧化发挥对急性肾损伤大鼠的保护作用[J].烟台大学学报（自然科学与工程版）,2017,30(2):124-130,7.基金项目
国家自然科学基金资助项目(81303259) （81303259）
山东省优秀中青年科学家科研奖励基金资助项目(BS2013YY046). （BS2013YY046）
