医药导报2017，Vol.36Issue(6)：606-609,4.DOI:10.3870/j.issn.1004-0781.2017.06.004
慢性应激和舍曲林对大鼠前额叶皮质维生素D代谢的影响
Effect of Chronic Unpredictable Mild Stress and Sertraline on Vitamin D Metabolism in Rat Prefrontal Cortex
摘要
Abstract
Objective To explore the relationship between vitamin D and depression and the effects of chronic unpredictable mild stress (CUMS) plus sertraline on vitamin D metabolism in rat brain.Methods Male SD rats were randomly divided into normal control group,normal control + sertraline group,CUMS group and CUMS+sertraline group.CUMS was used to build the animal model of depression.After chronic exposure to CUMS or sertraline (8 mg·kg-1·d-1) for 6 weeks,behavioral response (sucrose preference test) and vitamin D metabolism in the prefrontal cortex were analyzed.Results Compared with normal control group,6 weeks of CUMS procedure induced the rats to a depression-like state,decreased weight and sucrose preference,and increased the expression of enzymes involved in vitamin D activation and catabolism (CYP27B1 and CYP24A1,respectively) and vitamin D receptor (VDR) in rat prefrontal cortex.As compared with CUMS group,CYP27B1,CYP24A1 and VDR were significantly decreased in CUMS+sertraline group (P<0.01 or P<0.05).Conclusion CUMS activates vitamin D signaling in the brain of the animal models of depression,while sertraline alleviates depressive behavior and relieves stress-induced activation of vitamin D signaling,indicating that vitamin D signaling may be involved in the stress-induced depression.关键词
舍曲林/维生素D/应激,不可预见性,慢性/抑郁症Key words
Sertraline/Vitamin D/Stress,unpredictable mild,chronic/Depression分类
医药卫生引用本文复制引用
弓小雪,党瑞丽,郭玉金,蔡骅琳,江沛..慢性应激和舍曲林对大鼠前额叶皮质维生素D代谢的影响[J].医药导报,2017,36(6):606-609,4.基金项目
国家自然科学基金资助项目(81401113) （81401113）
