中心组合设计-响应面法优化银杏活脑胶囊的提取工艺OA北大核心CSTPCD
Extraction Process of Yinxing Huonao Capusle by Central Composite Design-Response Surface Method
目的 探索银杏活脑胶囊的提取工艺,优化制剂工艺.方法 以加水倍量、煎煮时间为考察因素,以紫丁香苷和大黄素转移率及固形物保留率的权重化值为综合评价指标,采用中心组合设计-响应面法对银杏活脑胶囊水提部位的提取工艺进行筛选.结果 银杏活脑胶囊水提部位的优选提取工艺为:加水量10倍,提取时间160 min,提取2次.结论 中心组合设计-响应面法用于筛选银杏活脑胶囊水提部位的提取工艺可行,预测性较高,所得优选工艺方法简便、可靠.
Objective To explore the extraction process of Yinxing Huonao capusle.Methods Central composite design-response surface method was used to optimize the extraction process with quantity of water and boiling time as main factors and with syringin transfer rate,emodin transfer rate and solids retention rate as evaluation index.Results The conditions of the optimized extraction process were as follows:10-fold water,extracting time of 160 min,extracting 2 times.C…查看全部>>
漆立军;覃鸿恩;黄华斌
湖北省恩施土家族苗族自治州中心医院药学部,恩施 445000湖北省恩施土家族苗族自治州中心医院药学部,恩施 445000湖北省恩施土家族苗族自治州中心医院药学部,恩施 445000
医药卫生
银杏活脑胶囊中心组合设计-响应面法提取工艺
Yinxing Huonao capusleCentral composite design-response surface methodologyExtraction process
《医药导报》 2017 (6)
668-672,5
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