医药导报2017，Vol.36Issue(6)：687-691,5.DOI:10.3870/j.issn.1004-0781.2017.06.022
前列地尔注射液治疗病毒性肝炎疗效和安全性Meta分析
Efficacy and Safety of Alprostadil Injection in Treatment of Viral Hepatitis:A Meta-analysis
任晓蕾 1詹轶秋 1贺真 1张海英 1张春燕 1冯婉玉1
作者信息
- 1. 北京大学人民医院药剂科,北京 100044
- 折叠
摘要
Abstract
Objective To systematically evaluate the efficacy and safety of alprostadil injection in patients with viral hepatitis.Methods Medline,Embase,The Cochrane Library,CBMdisc,CNKI,Wanfang Database and VIP were searched.The quality of included studies such as randomization,blinding,allocation concealment and loss of follow-up were evaluated and meta-analysis was performed by RevMan5.1 software.Results In total,14 RCTs and 1 232 patients were included.Meta-analysis showed that in patients with viral hepatitis,the total effective rate of alprostadil injection treatment was significantly superior to that of conventional therapy (P<0.000 01).Serious adverse drug reactions (ADRs) induced by alprostadil injection were not reported.Conclusion Alprostadil injection is effective and safe for treating viral hepatitis.However,the evidence is not strong due to the generally low methodological quality of RCTs.Further high quality and large sample-sized randomized controlled trials and more pharmacoeconomics studies should be carried out.关键词
前列地尔注射液/肝炎,病毒性/Meta分析Key words
Alprostadil injection/Hepatitis/viral/Meta-analysis分类
医药卫生引用本文复制引用
任晓蕾,詹轶秋,贺真,张海英,张春燕,冯婉玉..前列地尔注射液治疗病毒性肝炎疗效和安全性Meta分析[J].医药导报,2017,36(6):687-691,5.
