中国感染控制杂志2017，Vol.16Issue(5)：393-398,6.DOI:10.3969/j.issn.1671-9638.2017.05.001
神经外科术后患者静脉输注去甲万古霉素后血清及脑脊液药物浓度
Drug concentrations in the serum and cerebrospinal fluid of patients with intravenous drip of norvancomycin after neurosurgery procedure
摘要
Abstract
Objective To understand the changing characteristics of drug concentration in the serum and cerebrospinal fluid(CSF) after intravenous (IV) drip of norvancomycin in patients after neurosurgery procedure.Methods Patients with surgical cavity/ventricular drainages after neurosurgery procedure in a hospital in 2014 were selected, and they were divided into 2 groups according to the administration modes (12 in each group), conventional administration group: 0.8 g norvancomycin IV drip for 60 minutes, repeated every 12 hours;continuous administration group, 0.8 g norvancomycin, IV drip for 60 minutes, followed by 0.4 g of IV drip for 11 hours, then 0.4 g for 12 hours, serum and CSF specimens were collected at different time points after administration, concentration of norvancomycin was determined.Results Serum norvancomycin concentration reached a peak of (55.52±26.04) and (59.22±41.88) mg/L in conventional administration group and continuous administration group respectively, 24-hour serum concentration were (8.21±6.04) and (9.11±5.09)mg/L respectively;CSF norvancomycin concentration reached a peak of (16.31±11.15) and (8.82±8.91)mg/L in conventional administration group and continuous administration group respectively, 24-hour CSF concentration were (6.12±2.34)and (5.71±4.72)mg/L respectively;CSF penetration rate of conventional administration group was calculated by ratio of area under curve (AUCCSF/AUCserum), at 0-12 and 12-24 h hour were 63.3% and 59.0% respectively;in continuous administration group were 25.4% and 47.4% respectively.According to 95% of the minimum inhibitory concentration (MIC90) 2 mg/L of target bacteria methicillin-resistant Staphylococcus aureus (MRSA), AUC0-24/MIC90 in conventional administration group and continuous administration group were 192 and 184 respectively.Conclusion For patients who receives early use of standard dose of norvancomycin after neurosurgery procedure, CSF drug concentration after convention and continuous administration of norvancomycin can both reach MIC90 against target bacteria.关键词
去甲万古霉素/持续给药/血清药物浓度/脑脊液药物浓度/药物代谢动力学/药效动力学Key words
norvancomycin/continuous administration/serum drug concentration/cerebrospinal fluid drug concentration/pharmacokinetics/pharmacodynamics(PK/PD)分类
医药卫生引用本文复制引用
武元星,康建磊,王强,李太生..神经外科术后患者静脉输注去甲万古霉素后血清及脑脊液药物浓度[J].中国感染控制杂志,2017,16(5):393-398,6.基金项目
国家科技支撑计划基金资助项目(2012EP001004) （2012EP001004）
