中国感染控制杂志2017，Vol.16Issue(5)：399-403,5.DOI:10.3969/j.issn.1671-9638.2017.05.002
武汉地区宫颈感染人乳头瘤病毒患者年龄分布及感染类型特征
Age distribution and infection types of human papillomavirus cervical infection in patients in Wuhan region
摘要
Abstract
Objective To investigate the age distribution and types of human papillomavirus (HPV) cervical infection in patients in Wuhan region, so as to provide scientific basis for the prevention and treatment of HPV infection and cervical cancer.Methods 9 915 exfoliated cervical cell specimens from patients in Wuhan Medical and Health Center for Women and Children between January 2015 and March 2016 were performed HPV genotyping (21 subtypes), clinical data of 1 732 HPV positive cases were statistically analyzed.Results HPV-positive rates in ≤25, 26~, 36~, 46~, and ≥56 age groups were 22.15%, 15.90%, 17.04%, 19.97%, and 17.57%,respectively (χ2=36.587,P<0.01),HPV-positive rates in ≤25 and 46~ age groups were both higher than other age groups.There were significant differences in single infection and multiple infection rates among different age groups respectively(χ2=14.39, 36.51,respectively, both P<0.05),single infection rate was highest in 46~ and ≤25 age groups (15.41% and 15.24% respectively);multiple infection rates was highest in ≤25 and ≥56 age groups (6.90% and 5.86% respectively).The percentage of single infection and multiple infection were 75.58% and 24.42% respectively, the major single infection type was HPV high-risk subtype (84.34%),the major multiple infection types were high-risk and high-risk compound subtype as well as high-risk and low-risk compound subtype, accounting for 60.52% and 38.77% respectively.The main single infection types were HPV high-risk subtypes 33, 68, 31 and 16, as well as and low-risk subtype 11, the ratios of single infection to multiple infection were 3.13, 2.03, 1.71, 1.67 and 2.00 respectively.Conclusion Cervical infection rates in women in Wuhan region is high in ≤25 and 46~ age groups, there are differences in the distribution of different HPV subtypes of single infection and multiple infection.关键词
人乳头瘤病毒/宫颈癌/多重感染/导流杂交技术Key words
human papillomavirus/cervical cancer/multiple infection/flow-through hybridization technology分类
医药卫生引用本文复制引用
肖晗,孙红,向飞艳,夏倩,刘秀珍,向贇..武汉地区宫颈感染人乳头瘤病毒患者年龄分布及感染类型特征[J].中国感染控制杂志,2017,16(5):399-403,5.基金项目
国家自然科学基金资助项目(81201604) （81201604）
病毒学国家重点实验室开放基金项目(2015KF010) （2015KF010）
湖北省自然科学基金资助项目(2012FFB05301) （2012FFB05301）
武汉市卫生计生委临床医学科研项目(WX13B18) （WX13B18）
