中国感染控制杂志2017，Vol.16Issue(5)：413-416,422,5.DOI:10.3969/j.issn.1671-9638.2017.05.005
小儿肺炎克雷伯菌下呼吸道感染临床特点及耐药率
Clinical features and antimicrobial resistance of Klebsiella pneumoniae lower respiratory tract infection in children
摘要
Abstract
Objective To explore clinical features and antimicrobial resistance of Klebsiella pneumoniae (K.pneumoniae) lower respiratory tract infection(LRTI) in children.Methods Clinical data of 107 children with K.pneumoniae LRTI confirmed by sputum culture from January to December 2015 were analyzed retrospectively.Results 62.62% of children with LRTI were aged less than 6 months and 64.49% episodes occurred in autumn and winter.All cases had cough and 39 had fever, the main complications were type I respiratory failure, type Ⅱ respiratory failure, cardiac insufficiency, and electrolyte disturbance, 39 cases(36.45%) had complications involving two systems, 5 cases(4.67%)had complications involving three systems,47 cases (43.93%) met the diagnostic criteria of severe pneumonia.43 cases (40.19%) had primary underlying diseases, the major were congenital heart disease, preterm and low birth weight, and malnutrition.Children with imipenem-resistant bacteria infection were more prone to develop extrapulmonary complications than those with non-resistant pathogenic infection.The resistance rate of K.pneumoniae to amikacin was the lowest(9.35%).90 cases were recovered and markedly effective, 11 cases were effective, 4 cases were not healed and voluntarily discharged from hospital, and 2 cases died.Conclusion Children aged less than 6 months and with underlying diseases are prone to develop LRTI, and complications are more.关键词
儿童/下呼吸道感染/肺炎克雷伯菌/抗药性,微生物/耐药性/合理用药Key words
child/lower respiratory tract infection/Klebsiella pneumoniae/drug resistance/microbial/rational antimicrobial use分类
医药卫生引用本文复制引用
吴鹏,周凯,徐飞,王晓卫,姚开虎..小儿肺炎克雷伯菌下呼吸道感染临床特点及耐药率[J].中国感染控制杂志,2017,16(5):413-416,422,5.基金项目
国家自然科学基金(81371853) （81371853）
南京市科委资助项目(201605048) （201605048）
