中国临床药理学杂志2017，Vol.33Issue(7)：589-591,3.DOI:10.13699/j.cnki.1001-6821.2017.07.004
阿帕替尼片治疗晚期胃癌的临床研究
Clinical trial of apatinib tablets in the treatment of advanced gastric cancer
摘要
Abstract
Objective To study the clinical efficacy and safety of apatinib tablets combined with tegafur,gimeracil and oteracil potassium capsules(S-1) and oxaliplatin injections in the treatment of advanced gastric cancer.Methods A total of 90 patients with advanced gastric cancer were randomly divided into control group and treatment group with 45 cases per group.Control group was given 130 mg · m-2 oxaliplatin,intravenous infusion for 2 h in the first day + oral S-1 twice a day after breakfast and dinner for 14 days,the dosages were 40,50,60 mg per time for the patients with the surface area ＜ 1.25 m2,1.25-1.5 m2,＞ 1.5 m2,respectively.Treatment group orally received apatinib 850 mg qd,0.5 h after meal,on the basis of control group.Two groups were treated for 4 cycles with 3 weeks per cycle.The clinical efficacy and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 40.00％ (18/45 cases) and 24.44％ (11/45 cases),disease control rates in treatment and control groups were 77.78％ (35/45 cases) and 64.44％ (29/45 cases),the differences were statistically significant (P ＜ 0.05).In the treatment and control groups,the incidences of nausea and vomiting were 13.33％ and 11.11％;neutropenia were 11.11％ and 8.89％;diarrhea were 2.22％ and 2.22％;hand-foot syndrome were 4.44％ and 4.44％;thrombocytopenia were 6.67％ and 8.89％,without significant differenee(P ＞0.05).In the treatment and control groups,the incidences of fatigue were 2.22％ and 11.11％;hypertension were 2.22％ and 11.11％;proteinuria were 0 and 6.67％,the differences were statistically significant (P ＜ 0.05).Conclusion Apatinib tablets combined with S-1 and oxaliplatin injections have a definitive clinical efficacy and safety in the treatment of advanced gastric cancer.关键词
阿帕替尼片/替吉奥胶囊/奥沙利铂注射剂/晚期胃癌Key words
apatinib tablet/tegafur, gimeracil and oteracil potassium capsule/oxaliplatin injection/advanced gastric cancer分类
医药卫生引用本文复制引用
文峰,向燕,王雷..阿帕替尼片治疗晚期胃癌的临床研究[J].中国临床药理学杂志,2017,33(7):589-591,3.基金项目
四川省科技基金资助项目(120078) （120078）
