中国临床药理学杂志2017，Vol.33Issue(7)：592-594,3.DOI:10.13699/j.cnki.1001-6821.2017.07.005
黄体酮注射液联合硝苯地平片治疗输尿管上段结石的临床研究
Clinical trial of progesterone combined with nifedipine in the treatment of upper ureteral calculi
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of progesterone combined with nifedipine in the treatment of upper ureteral calculi.Methods A total of 94 patients with upper ureteral calculi werc divided into control group and treatment group,47 cases in cach group.Patients in control group were given anisodamine hydrochloride injection 5-10 mg by intramuscular injection,qd.Patients in treatment group received progesterone injection 20 mg by intramuscular injection,bid and nifedipine tablets 10 mg by under tongue,tid.All patients were treated for 14 d.The clinical efficacy,C-reactive protein(CRP),interleukin-6 (IL-6) and adverse drug reactions were compared between the two groups.Results The clinical efficacy in treatment group was 95.74％ (45/47 cases),had significant difference with that in control group,which was 82.98％ (39/47 cases,P ＜0.05).The levels of CRP and IL-6 in treatment group were (2.17 ± 0.25) mg · L-1,(4.72 ± 0.51) ng · L-1,had significant difference with those in control group,which were(3.45 ±0.42) mg· L-1,(8.34±0.89) ng · L-1 (P ＜0.05).The main adverse drug reactions in treatment group were dry mouth,blurred vision and rashes,the incidence rate was 6.38％ (3/47 cases).The main adverse drug reactions were dry mouth,rapid heart beat,difficulty urinating and rashes in control group,the incidence rate was 10.64％ (5/47 cases,P ＞ O.05).Conclusion Progesterone combined with nifedipine in the treatment of upper ureteral calculi was effective with high safety.关键词
黄体酮/硝苯地平/输尿管上段结石/C-反应蛋白/白细胞介素-6Key words
progesterone/nifedipine/ureteral calculi/C-reactive protein/interleukin-6分类
医药卫生引用本文复制引用
黄色兰,叶燕乐,沈倚天..黄体酮注射液联合硝苯地平片治疗输尿管上段结石的临床研究[J].中国临床药理学杂志,2017,33(7):592-594,3.基金项目
泉州市卫生科研基金资助项目[泉卫函(2014)267号] （2014）
