中国临床药理学杂志2017，Vol.33Issue(7)：649-652,4.DOI:10.13699/j.cnki.1001-6821.2017.07.023
甘氨双唑钠联合放疗治疗原发性鼻咽癌的有效性和安全性的Meta分析
Meta-analysis of effectiveness and safety of sodium glycididazole combined with radiotherapy in the treatment of nasopharyngeal carcinoma
余克富 1王婷 2朱斌 1赵志刚 1李新刚1
作者信息
- 1. 首都医科大学附属北京天坛医院药学部,北京100050
- 2. 北京丰台区南苑社区卫生服务中心药剂科,北京100076
- 折叠
摘要
Abstract
Objective To evaluate the effectiveness of sodium glycididazole combined with radiotherapy in the treatment of nasopharyngeal carcinoma.Methods Randomized controlled trials (RCTs) were retrieved from Cochrane library,PubMed,EMbase,CNKI,VIP,CBM,Wanfang database;other relevant journals were searched manually.The date of publication was up to November 2016.RCTs about sodium glycididazole combined with radiotherapy in the treatment of nasopharyngeal carcinoma were included.Treatment group was treated with odium glycididazole combined with radiotherapy,and control group was treated with radiotherapy alone.The quality of included studies was evaluated and per-formed by using Rev Man 5.0 statistical software.Results A total of 18RCTs were included,involving 1241 patients.Meta-analysis showed that complete remission rate (CR)between treatment group and control group were 90.37％ and 72.86％.Also the total remission rate was 69.23％ and 44.60％ respectively.All discrepancy had statistical difference.The incidence between treatment group and control group were 36.36％ and 36.24％,but the diversity had no statistical difference.Conclusion Short-term efficacy of sodium glycididazole combined with radiotherapy was better than radiotherapy alone for nasopharyngeal carcinoma.And,enhancement of adverse reactions was not emerged.关键词
甘氨双唑钠/鼻咽癌/放射治疗/Meta分析Key words
sodium glycididazole/nasopharyngeal carcinoma/radiation therapy/Meta-analysis分类
医药卫生引用本文复制引用
余克富,王婷,朱斌,赵志刚,李新刚..甘氨双唑钠联合放疗治疗原发性鼻咽癌的有效性和安全性的Meta分析[J].中国临床药理学杂志,2017,33(7):649-652,4.
