中国临床药理学杂志2017，Vol.33Issue(8)：678-680,3.DOI:10.13699/j.cnki.1001-6821.2017.08.002
性别和乙醛脱氢酶2基因多态性对冠心病患者血浆脂蛋白(a)水平的影响
Effects of gender and polymorphism of aldehyde dehydrogenases 2 genotypes on lipoprotein (a) among patients with coronary heart disease
李巧艳 1张锦霞 1安松涛 2段虹飞 1马永成 1赵宁民 1赵红卫 1秦玉花1
作者信息
- 1. 河南省人民医院药学部,郑州450003
- 2. 河南省人民医院心内科,郑州450003
- 折叠
摘要
Abstract
Objective To explore the effects of gender and polymorphism of aldehyde dehydrogenases 2 (ALDH2) genotypes on lipoprotein (a) [Lp(a)] levels among patients with coronary heart disease (CHD) disease.Methods A total of 772 subjects (561 males and 211 females) diagnosed with CHD were enrolled in this study.Among the male patients the effects of smoking and drinking habits on Lp(a) levels were studied.Then after excluding the effects of smoking and drinking habits,the effects of gender on Lp (a) levels were studied.Finally,the effects of ALDH2 genotypes were discussed.Results In this study,we found that male patients with different life styles of alcohol drinking and tobacco smoking got similar Lp(a) levels [(24.82 ± 17.80) vs (24.92 ± 19.72) mg · dL-1 and (P ＞ 0.05)].Gender and ALDH2 genotypes had significant effects on Lp (a) levels.The female patients got higher Lp (a) levels than the male patients [(30.38 ± 23.01) vs (25.47 ± 19.02) mg · dL-1 and (P ＜0.01)].The patients with mutant ALDH2 genotypes got higher Lp (a) levels than that with wide types [(29.06 ±-24.62) vs (33.02 ± 19.27)mg · dL-1 and P ＞ 0.05].Conclusion Female patients combined with mutant ALDH2 genotypes were risk factors for high Lp (a) levels,which may also increase the risk of getting CHD.关键词
性别/乙醛脱氢酶2基因型/脂蛋白(a)/冠心病Key words
gender/aldehyde dehydrogenases 2/lipoprotein(a)/coronary heart disease分类
医药卫生引用本文复制引用
李巧艳,张锦霞,安松涛,段虹飞,马永成,赵宁民,赵红卫,秦玉花..性别和乙醛脱氢酶2基因多态性对冠心病患者血浆脂蛋白(a)水平的影响[J].中国临床药理学杂志,2017,33(8):678-680,3.
