中国临床药理学杂志2017，Vol.33Issue(8)：681-683,3.DOI:10.13699/j.cnki.1001-6821.2017.08.003
丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床研究
Clinical trial of Salvia miltiorrhiza injection combined with nimodipine sustained release tablets in the treatment of hypertensive hemorrhagic stroke
摘要
Abstract
Objective To observe the clinical efficacy and safety of Salvia miltiorrhiza injection combined with nimodipine sustained release tablets in the treatment of hypertensive hemorrhagic stroke.Methods The 106 patients with hypertensive hemonrhagic stroke were divided into control group (n =64 cases) and treatment group (n =42 cases).Control group was given oxygen,suction,control brain edema,maintain electrolyte balance,nutrition,brain cells and other conventional treatment.Treatment group was given Salvia miltiorrhiza injection 10 mg · d-1,the speed of intravenous infusion ＜ 1 mg· h-1 + nimodipine sustained release tablets 20 mg tid oral,on the basis of control group.Two groups were treated for 14 d.The clinical efficacy,hematoma absorption and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 95.24％ (40/42 cases) and 85.94％ (55/64 cases),with significant difference (P ＜ 0.05).Mter treatment for 14,28 d,the mean hematoma volume in treatment group were (8.26±4.39),(6.76 ±3.16) mL,which in control group were (12.41 ±5.02),(9.33 ±4.78) mL,with significant difference (P ＜ 0.05).The adverse drug reactions in treatment group were headache,gastrointestinal reaction,hypotension,thrombocytopenia and skin prick,which in control group were headache and gastrointestinal reaction.The incidences of adverse drug reactions in treatment and control groups were 19.04％ (8/42 cases) and 7.81％ (5/64 cases),without significant difference (P ＞0.05).Conclusion Salvia miltiorrhiza injection combined with nimodipine sustained release tablets has a definitive clinical efficacy in the treatment of hypertensive hemorrhagic stroke,which can improve the absorption of hematoma,without increasing the incidence of adverse drug reactions.关键词
丹参注射液/尼莫地平缓释片/高血压出血性脑卒中/安全性Key words
Salvia miltiorrhiza injection/nimodipine sustained release tablet/hypertensive hemorrhagic stroke/safety分类
医药卫生引用本文复制引用
王爱岳,李强,余丹,周治平..丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床研究[J].中国临床药理学杂志,2017,33(8):681-683,3.基金项目
海南省自然科学基金资助项目(30716) （30716）
