中国临床药理学杂志2017，Vol.33Issue(8)：690-693,4.DOI:10.13699/j.cnki.1001-6821.2017.08.006
盐酸多奈哌齐片联合司来吉兰片治疗帕金森病的临床研究
Clinical trial of donepezil hydrochloride tablets combined with selegiline tablets in treatment of Parkinson's disease
摘要
Abstract
Objective To observe the curative efficacy and safety of donepezil hydrochloride tablets combined with selegiline tablets in treatment of Parkinson's disease.Methods Ninety-two patients with Parkinson's disease were randomly divided into control group (46 cases) and treatment group (46 cases).Control group was given selegiline 5 mg,bid oral.Treatment group was given onepezil hydrochloride 5 mg,bid oral,on the basis of control group.Two groups were treated for 2 months.The clinical efficacy,unified parkinson disease rating scale (UPDRS),montreal cognitive assessment (MoCA),mini-mental state examination (MMSE),Barthel index (BI),superoxide dismutase (SOD),malondialdehyde (MDA) and glutathione (GSH)and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 95.65％ (44/46 cases)and 76.09％ (35/46 cases) with significant difference (P ＜ O.05).After treatment,the main indexes in treatment and control groups were compared:UPDRS were (47.03 ± 7.21),(61.67 ± 7.28) point;MoCA were (27.04 ± 1.97),(20.67 ± 2.15) point;MMSE were (25.63 ±3.57),(22.25 ±3.64)point;Barthel indexes were (79.29 ±9.15),(68.43 ±9.32) point;SOD were (117.54 ± 16.14),(98.43 ± 15.12) kU · L-1;MDA were (5.13 ± 1.83),(5.96 ± 2.14) μmol · L-1;GSH were (47.66 ± 8.57),(35.27 ± 8.35) μmol · L-1,with significant difference (P ＜ 0.05).The adverse drug reactions in two groups were dry mouth,sleep disorders,nausea,diarrhea and loss of appetite,the incidences of adverse drug reactions in treatment and control groups were 32.61％ and 23.91％,without significant difference (P ＞0.05).Conclusion Donepezil hydrochloride tablets combined with selegiline tablets has a definitive clinical efficacy in the treatment of Parkinson's disease,which can improve the cognitive function,daily life ability and mental state,reduce oxidative stress level,without increasing the incidence of drug adverse reactions.关键词
多奈哌齐片/司来吉兰片/帕金森病/认知功能/氧化应激Key words
donepezil tablet/selegiline tablet/Parkinson's disease/cognitive function/oxidative stress分类
医药卫生引用本文复制引用
潘可达,陈为安,方慧,郑默,刘艳..盐酸多奈哌齐片联合司来吉兰片治疗帕金森病的临床研究[J].中国临床药理学杂志,2017,33(8):690-693,4.基金项目
浙江省自然科学基金资助项目(LY15H090019) （LY15H090019）
