中国内镜杂志2017，Vol.23Issue(5)：28-33,6.DOI:10.3969/j.issn.1007-1989.2017.05.007
止血绫修复内镜黏膜下剥离术后创面的应用研究
Application of hemostatic silk shielding on ulcers induced by endoscopic submucosal dissection
摘要
Abstract
Objective To investigate the clinical value of hemostatic silk in prevention of wound bleeding and wound healing after endoscopic submucosal dissection (ESD). Methods Experiment group: animal model was made by rabbit underwent ESD simulation in its' stomach and laying hemostatic silk on its' wound;control group: animal model was made by pig underwent ESD simulation in its' colon without any healing management. All the ulcers sites were endoscopically and pathologically examined to evaluate the hemorrhage and healing of the wound on 3 days, 1 week, 2 weeks and 4 weeks after the procedure. Results The blood loss in experiment group was significantly lower than that in control group. The wounds of all the experimental pigs underwent colon ESD successfully covered with hemostatic silk postoperatively. Endoscopic pathological examination shown better healing procedure in experiment group. No procedure-related adverse event occurred in both groups. Conclusions Hemostatic silk has potential application value in healing the wound after ESD demonstrated by animal experiment.关键词
内镜黏膜下剥离术/动物模型/止血绫/创面修复Key words
endoscopic submucosal dissection (ESD)/animal models/hemostatic silk/the healing of the wound分类
医药卫生引用本文复制引用
陈钟,蔡艺玲,马明,韩忠政,张秦,王君尧,唐庆林,张华玉,张鸣青..止血绫修复内镜黏膜下剥离术后创面的应用研究[J].中国内镜杂志,2017,23(5):28-33,6.基金项目
南京军区医学科技创新重点项目(No:15ZD026) （No:15ZD026）
吴阶平医学基金会临床科研专项资助基金(No:320.6750.1523) （No:320.6750.1523）
175医院多学科项目(No:14LYG002) （No:14LYG002）
南京军区医学科技创新面上项目(No:15MS109) （No:15MS109）
175医院青年苗圃课题(No:16Y002) （No:16Y002）
