中国比较医学杂志2017，Vol.27Issue(5)：1-3,3.DOI:10.3969.j.issn.1671-7856.2017.05.001
SPF巴马小型猪的培育及应用
Breeding and application of SPF Bama miniature pig
摘要
Abstract
In this study, a Specific Pathogen-Free (SPF) Bama miniature pig herd was established.The standards for breeding experimental pigs, genetic test and microbiological quality control had been drafted.The local standards of Heilongjiang province "SPF" technical specifications for microbiological monitoring of pigs had been formulated.The genetic and microbiological quality criterion had been used to control of the SPF pig herd.Classical swine fever virus (CSFV) and highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) infection models of Bama miniature pigs were established, especially the infection miniature pig model of PRRSV was used to evaluated commercially vaccine.The comparison of the cytokine homology between Bama miniature pigs and domestic pigs showed that the Bama miniature pigs can be used to instead of domestic pigs as an ideal experiental animal.At present the SPF Bama miniature pig colonies have been widely used to study the mechanism of prevention and pathogenic in the classical swine fever virus, porcine reproductive and respiratory syndrome virus and porcine transmissible gastroenteritis virus and porcine circovirus and so on.The completion of the project solved the bottleneck problem of the experimental pig usage which provided a new ideal experimental animal for animal disease and life science research.关键词
巴马小型猪/无特定病原体/培育/感染模型Key words
Bama miniature pig/Specific Pathogen-Free/Breeding/Infection model分类
医药卫生引用本文复制引用
姜骞,韩凌霞,司昌德,林欢,高彩霞,郭东春,张伟,刘家森,曲连东..SPF巴马小型猪的培育及应用[J].中国比较医学杂志,2017,27(5):1-3,3.基金项目
中央级公益性科研院所基本科研业务费专项(2008-04,2009-15) （2008-04,2009-15）
黑龙江省地方标准项目(2014-38) （2014-38）
黑龙江省科技攻关(PC08S01). （PC08S01）
