中国比较医学杂志2017，Vol.27Issue(5)：6-8,3.DOI:10.3969.j.issn.1671-7856.2017.05.003
化学物(药物)毒性测试替代体系的建立及应用
Establishment and application of toxicity testing alternative system for chemicals(new drugs)
摘要
Abstract
There are some shortcomings of animal experiments applied in chemical toxicity testing, such as long period, large cost, species differences and dose differences, which limit the use of animal experiments' results in predicting human toxicity.Accordingly, we established a toxicity testing alternative screening system in line with the toxicity endpoints which required in chemical safety evaluation and risk assessment (genotoxicity, carcinogenicity, reproductive toxicity, acute toxicity and general toxicity) based on "3R" principles (replacement, reduction, refinement) for animal experiments.This system covers most of the endpoints of toxicity assessment, and molecular biology technology was also applied to integrate the toxicity test, as well as some operation was optimized in order to shorten the experimental period, reduce experimental costs, improve animal welfare.Furthermore, the results from the screening system have higher clinical relevance because it is based on the toxicity mechanisms.关键词
毒性测试/替代策略/减少性替代/替代性研究/优化性替代Key words
Toxicity testing/Alternative strategy/Replacement/Reduction/Refinement分类
医药卫生引用本文复制引用
施畅,马华智,王全军,吴纯启,原野,石富江,荆淑芳,王建京,廖明阳..化学物(药物)毒性测试替代体系的建立及应用[J].中国比较医学杂志,2017,27(5):6-8,3.基金项目
北京市科委科技计划项目(H030230150130) （H030230150130）
国家科技重大专项课题(2008ZX09305-003,2012ZX09301-003-008,2013ZX09301303). （2008ZX09305-003,2012ZX09301-003-008,2013ZX09301303）
