中国比较医学杂志2017，Vol.27Issue(5)：9-11,3.DOI:10.3969.j.issn.1671-7856.2017.05.004
长爪沙鼠NAFLD模型的建立及其遗传学的研究
Preliminarily genetic characterizations of nonalcoholic fatty liver disease mongolian gerbil
摘要
Abstract
Non-alcoholic fatty liver disease (NAFLD) has become one of the major metabolic diseases.In view of the defects of traditional animal models, this study was the first to establish the NAFLD model of Mongolian gerbil (Meriones unguiculatus) with simple feed formula which is similar to human (from simple fatty liver to steatohepatitis, fibrosis,Liver cirrhosis).This study discussed the mechanism of rapid fatty liver deposition in Mongolian gerbil, revealed its molecular mechanism,main regulatory target and network function of fatty liver susceptibility.We provide a new animal model of NAFLD with relatively clear background and less time-consuming for clinical treatment and new drug development.The theoretical and practical basis for the breeding of inbred strain NAFLD gerbil was established.关键词
非酒精性脂肪性肝病/长爪沙鼠模型/遗传基础Key words
Nonalcoholic fatty liver disease(NAFLD)/Mongolian gerbil/Genetic Characterizations分类
医药卫生引用本文复制引用
刘月环,吴旧生,应华忠,徐承富,石巧娟,余陈欢..长爪沙鼠NAFLD模型的建立及其遗传学的研究[J].中国比较医学杂志,2017,27(5):9-11,3.基金项目
浙江省自然科学基金(Y3080126,Y3110366,LY16H030011) （Y3080126,Y3110366,LY16H030011）
浙江省科技厅公益技术应用研究项目(2011C37096,2015C37102) （2011C37096,2015C37102）
浙江省医药卫生平台重点项目(2011ZDA002) （2011ZDA002）
浙江省医药卫生优秀青年人才基金(2007QN001) （2007QN001）
浙江省医学科学院优秀青年科技人才基金(A80703Q). （A80703Q）
