中国比较医学杂志2017，Vol.27Issue(5)：16-18,3.DOI:10.3969.j.issn.1671-7856.2017.05.006
小型猪慢性心肌缺血模型的建立与无创遥测技术的应用
Establishment of chronic myocardial ischemia model in minipigs and application of noninvasive telemetry technique
摘要
Abstract
In order to establish the minipig model of chronic myocardial ischemia and apply non-invasive telemetry technique, the minipig model of chronic myocardial ischemia was made induced by Vitamin D3, isoproterenol and combined with high fat diet, and the non-invasive telemetry technique was used to detect and evaluate the symptoms of minipig model of chronic myocardial ischemia.Moreover, the effects of transport stress and the risk factors of atherosclerosis (AS) induced by high fat diet among Wuzhishan minipigs, Bama minipigs and Tibetan minipigs were also evaluated.Our study has successful established the Bama minipig model of chronic myocardial ischemia and the technical specification for evaluation,.The non-invasive telemetry technique can be used to detect and evaluate the symptoms of chronic myocardial ischemia model, and defines minipigs at least need to keep for more than 4 weeks after transport stress to adaptive recovery period.In addition, the different characteristics of AS risk factors such as hyperlipidemia, hypertension and hyperinsulinemia were observed in Wuzhishan minipigs, Bama minipigs and Tibetan minipigs in high fat environment, and this provides a reference for the selection and application of minipigs in the research of cardiovascular diseases.关键词
小型猪/慢性心肌缺血/无创遥测技术/动脉粥样硬化/心率变异性/适应恢复期Key words
Minipig/Chronic myocardial ischemia/Non-invasive telemetry technique/Atherosclerosis/Heart rate variability/Adaptive recovery period分类
医药卫生引用本文复制引用
陈民利,朱科燕,潘永明,陈亮,徐孝平,王德军,杨玉伟,陈方明,蔡月琴,徐剑钦..小型猪慢性心肌缺血模型的建立与无创遥测技术的应用[J].中国比较医学杂志,2017,27(5):16-18,3.基金项目
省部共建科研基金(WKJ2009-2-032) （WKJ2009-2-032）
浙江中医药大学比较医学创新团队(XTD201301). （XTD201301）
