中国比较医学杂志2017，Vol.27Issue(5)：60-63,4.DOI:10.3969.j.issn.1671-7856.2017.05.014
松花粉对环磷酰胺增效减毒作用研究
Synergism and attenuation effects of Pini Pollen on cyclophosphamide
摘要
Abstract
Objective To investigate the synergism and attenuation effects of Pini Pollen on cyclophosphamide chemotherapy in model mice.Methods The models of mouse were induced with S180 tumor and cyclophosphamide.The tumor inhibiting rates, hematology, Liver function, giant cell phagocytosis, hemolysin level and indexes of thymus and spleen were determined to evaluate the synergism and attenuation effects of Pini Pollen(150,300,600 mg/kg) on cyclophosphamide chemotherapy.Results Compared with cyclophosphamide chemotherapy group,the tumor inhibiting rates,white blood cell number,giant cell phagocytosis, hemolysin level and indexes of thymus and spleen were increased, at the same time liver function damage were alleviated significantly in cyclophosphamide plus Pini Pollen groups.Conclusions Pini Pollen has a remarkable synergism and attenuation effects on cyclophosphamide chemotherapy through its immune adjustment functions.关键词
松花粉/免疫调节/增效减毒/环磷酰胺Key words
Pini Pollen/Synergism and attenuation/Immune adjustment/Cyclophosphamide分类
医药卫生引用本文复制引用
巩萍,孙铜,戴晓莉,马玉奎..松花粉对环磷酰胺增效减毒作用研究[J].中国比较医学杂志,2017,27(5):60-63,4.基金项目
山东省自主创新及成果转化专项(2014ZZCX02104). （2014ZZCX02104）
