中国实用儿科杂志2017，Vol.32Issue(5)：366-370,5.DOI:10.19538/j.ek2017050612
儿童急性淋巴细胞白血病血小板参数及血小板膜糖蛋白临床意义研究
A study on platelet indices and platelet membrane glycoprotein in children with acute lymphocytic leukemia
摘要
Abstract
Objective To investigate the change of the platelet state and function in acute lymphocytic leukemia.Methods The changes of platelet indices (PLT,PCT,MPV,PDW),immature platelet fraction (IPF％),immature platelet counts (IPC),granule membrane glycoprotein of platelet (CD62p) and PAC-1 were obtained by using automatic blood cell analyzer and whole blood flow cytometry (FCM) respectively,in children with acute lymphocytic leukemia (ALL),ALL in first complete remission (ALL-CR1) and children undergoing elective surgical procedure (control group).Results (1)Without addition of platelet agonists ADP,expression of platelet surface activated CD62p and PAC-1 in ALL was higher than that in control group (P ＜ 0.05),while expression of platelet surface activated PAC-1 in ALL-CR1 was higher than that in control group (P ＜ 0.05),and lower than that in ALL (P ＜ 0.05);(2)With addition of platelet agonists ADP,expression of platelet surface activated CD62p and PAC-1 in ALL was lower than that in control group (P ＜ 0.05),while expression of platelet surface activated PAC-1 in ALL-CR1 was lower than that in control group (P ＜ 0.05),and higher than that in ALL (P ＜ 0.05);(3) PLT,PCT and MPV in ALL was lower than that in control group and ALL-CR1 (P＜0.05);(4) IPF％ in ALL was higher than that in control group and ALL-CR1 (P ＜ 0.05),and IPC was lower than that in control group and ALL-CR 1 (P ＜ 0.05).Conclusion The children who are newly diagnosed with acute lymphocytic leukemia have peripheral platelet reactivity and platelet function defects.Platelet indices and platelet membrane glycoprotein can be used as effective indicators to judge the effect on ALL.关键词
急性淋巴细胞白血病/血小板参数/PAC-1/颗粒膜糖蛋白/血小板功能Key words
acute lymphocytic leukemia/platelet indices/PAC-1/CD62p/platelet function分类
医药卫生引用本文复制引用
黄喆,刘文君,曹汴川,罗锋,胡晓,陈红英,刘春艳,沈红书..儿童急性淋巴细胞白血病血小板参数及血小板膜糖蛋白临床意义研究[J].中国实用儿科杂志,2017,32(5):366-370,5.基金项目
四川省卫生厅科研基金资助(20110004) （20110004）
