中国现代医学杂志2017，Vol.27Issue(9)：13-18,6.DOI:10.3969/j.issn.1005-8982.2017.09.003
硫化氢减轻糖尿病小鼠胰岛素抵抗的作用机制研究
Hydrogen sulfide alleviates insulin resistance by reducing apoptosis of adipose cells in diabetic mice
孙耀 1贾云宏1
作者信息
- 1. 锦州医科大学 药学院,辽宁 锦州 121000
- 折叠
摘要
Abstract
Objective To investigate the effect of hydrogen sulfide on insulin resistance and its mechanism in mice with diabetes mellitus. Methods C57Bl6/J mice were randomly divided into normal control group, dia-betes mellitus group, low-dose therapy group, high-dose therapy group and positive control group. Diabetes mellitus models were established by high-fat diet and tetraoxypyrimidine. Caspase-3 activity, Bcl-2 and Bax expressions in adipose tissue were measured, as well as fasting plasma glucose, fasting serum insulin and hy-drogen sulfide in plasma. Then, insulin sensitivity index was calculated. Results Caspase-3 activity and Bax level were down-regulated, while Bcl2 was up-regulated in mice with diabetes mellitus, and all the indexes recovered after therapy with sodium hydrosulfide. Conclusions Hydrogen sulfide could alleviate insulin resis-tance by reducing the apoptosis of adipose cells.关键词
硫化氢/糖尿病/胰岛素抵抗/脂肪组织/凋亡Key words
hydrogen sulfide/diabetes mellitus/insulin resistance/adipose tissue/apoptosis分类
医药卫生引用本文复制引用
孙耀,贾云宏..硫化氢减轻糖尿病小鼠胰岛素抵抗的作用机制研究[J].中国现代医学杂志,2017,27(9):13-18,6.
