中国现代医学杂志2017，Vol.27Issue(9)：44-48,5.DOI:10.3969/j.issn.1005-8982.2017.09.009
汉族人系统性红斑狼疮和狼疮肾炎与IL-22受体基因多态性的关系
Relationships of systemic lupus erythematosus and lupus nephritis in Han population with IL-22 receptor gene polymorphisms*
摘要
Abstract
Objective To study the interleukin-22 (IL-22) receptor gene polymorphisms in Han patients with systemic lupus erythematosus (SLE), and to examine its relationships with SLE and lupus nephritis. Methods A total of 360 patients with SLE (group A) and 360 health people (control group) in the First Hos-pital of Jilin University from January 2012 to June 2016 were selected as research subjects. The group A was further divided into group C (lupus nephritis group) and group D (without lupus nephritis group). The correla-tions of rs3795299 genotypes and allele frequency of IL-22R1 gene with SLE, lupus nephritis and clinical characteristics of SLE were observed. Results The differences in the rs3795299 genotypes and allele frequency of IL-22R1 gene were not statistically significant between the group A and the group B (P>0.05). The pro-portion of GG genotype in the group C was higher than that in the group D (P<0.05), while the proportions of CG and CC genotypes in the group C were lower than those in the group D (P<0.05). The frequency of allele G in the group C was lower than that in the group D (P<0.05), but the frequency of allele C in the group C was higher than that in the group D (P<0.05). The distribution of allele frequency of rs3795299 locus in IL-22R1 gene was significantly different between the SLE patients with arthritis, facial redness, light sensitivity or oral ulcers and the SLE patients without arthritis, facial redness, light sensitivity or oral ulcers (P<0.05). Conclusions In Chinese Han population, IL-22R1 gene rs3795299 gene polymorphism is not in significant correlation with the susceptibility of SLE, but is related to lupus nephritis and clinical features of SLE.关键词
系统性红斑狼疮/IL-22受体/基因多态性/狼疮肾炎Key words
systemic lupus erythematosus/IL-22 receptor/gene polymorphism/lupus nephritis分类
医药卫生引用本文复制引用
鄢海波,赵令,马宁,姜振宇..汉族人系统性红斑狼疮和狼疮肾炎与IL-22受体基因多态性的关系[J].中国现代医学杂志,2017,27(9):44-48,5.基金项目
国家自然科学基金(No:3A515BF53428) （No:3A515BF53428）
