中国现代医学杂志2017，Vol.27Issue(9)：59-63,5.DOI:10.3969/j.issn.1005-8982.2017.09.012
IgA肾病肾组织中OPN、TGF-β1的表达及其与临床、病理的关系
Expressions of OPN and TGF-β1 in renal tissue of patients with IgA nephropathy and their correlations with clinical and pathological parameters*
摘要
Abstract
Objective To investigate the expressions of osteopontin (OPN) and transforming growth factor-β1 (TGF-β1) in renal biopsy tissue of IgA nephropathy and their relationships with clinicopathological parameters. Methods The levels of OPN and TGF-β1 in the renal tissues of 60 cases of IgA nephropathy, 30 cases of minimal change nephropathy (MCD) and 20 people with normal kidneys were detected with immunohistochemical SP method. Serum creatinine, creatinine clearance and 24-h urinary protein were determined. Haas typing and Katafuchi grading were used to evaluate the pathological changes of IgA nephropathy patients. The correlations of OPN and TGF-β1 in renal tissues with clinical parameters and pathological changes were analyzed. Results The levels of serum creatinine and 24-h urinary protein, and the expressions of OPN and TGF-β1 in the IgA nephropathy group of Haas type Ⅰ-Ⅴ were higher than those in the MCD control group and the healthy control group, but the creatinine clearance was lower than that in the MCD and healthy control groups (P<0.05). The expressions of OPN and TGF-β1 in the type Ⅳ and Ⅴ renal tissues were significantly higher than those in the type Ⅰ, Ⅱ and Ⅲ renal tissues (P<0.05). The levels of serum creatinine and 24-h urinary protein and the expressions of OPN and TGF-β1 in the IgA nephropathy group of Katafuchi grade 0-Ⅲ were higher than those in the MCD control group and the healthy control group, while the creatinine clearance was lower than that in the MCD and healthy control groups (P< 0.05). The expressions of OPN and TGF-β1 in the renal tissue of IgA nephropathy group significantly rose with the increase of Katafuchi grade (P<0.05). The Spearman correlation analysis showed that Haas type and Katafuchi grade were in positive correlations with OPN and TGF-β1 levels in the renal tissues and 24-h urinary protein in the IgA nephropathy patients (P<0.05). Conclusions OPN and TGF-β1 may play important roles in the pathogenesis of IgA nephropathy and renal tubulointerstitial injury.关键词
IgA肾病/肾活检组织/骨桥蛋白/转化生长因子/临床病理Key words
IgA nephropathy/renal biopsy/osteopontin/transforming growth factor/clinical pathology分类
医药卫生引用本文复制引用
李海剑,程根阳,刘慧,李亦彤,陶雅非,王建刚,李玉东..IgA肾病肾组织中OPN、TGF-β1的表达及其与临床、病理的关系[J].中国现代医学杂志,2017,27(9):59-63,5.基金项目
河南省科技攻关计划项目(No:152102310056) （No:152102310056）
