中国现代医学杂志2017，Vol.27Issue(9)：87-90,4.DOI:10.3969/j.issn.1005-8982.2017.09.018
结肠癌患者肿瘤微环境中T细胞亚群与肿瘤细胞转移的关系
Correlations between T cell subsets in tumor microenvironment and tumor cell metastasis in patients with colon cancer*
摘要
Abstract
Objective To investigate the relationships between T cell subsets in tumor microenvironment and tumor cell metastasis in patients with colon cancer. Methods A total of 89 patients with colon cancer in our hospital were enrolled. All patients underwent resection of colon cancer. The tumor specimens were collected. CD4+T cells, CD8+T cells and regulatory T cells in the tumor tissues were detected, and their correlations with clinical features of colon cancer patients were studied. Results With the increase of TNM staging, CD4+T cells and regulatory T cells increased, and CD8+T cells decreased (P<0.05). The regulatory T cells of the patients with well-differentiated, moderately-differentiated and poorly-differentiated colon cancers were (6.59 ± 1.87)%, (7.27 ± 1.81)% and (8.12 ± 1.92)% respectively, and the differences were statistically significant (P<0.05). CD4+T cells and regulatory T cells were increased, while CD8+T cells were decreased in the patients with lymph node metastasis (P<0.05). The regulatory T cells of adenocarcinoma, mucinous carcinoma and undifferentiated carcinoma were (6.82 ± 1.88) %, (7.28 ± 1.82) % and (8.22 ± 1.91) %respectively, and the differences were statistically significant (P<0.05). Conclusions The imbalance of T cell subsets in tumor microenvironment is related to the metastasis of tumor cells, therefore regulation of the T cells in the microenvironment could improve the prognosis.关键词
结肠癌/肿瘤微环境/T细胞/转移Key words
colon cancer/tumor microenvironment/T cell/metastasis分类
医药卫生引用本文复制引用
李宝龙,刘轲,计鹏飞,万晓晨..结肠癌患者肿瘤微环境中T细胞亚群与肿瘤细胞转移的关系[J].中国现代医学杂志,2017,27(9):87-90,4.基金项目
2014年浙江省医药卫生一般研究计划(No:2014KYA003) （No:2014KYA003）
