浙江医学2017，Vol.39Issue(7)：501-504,4.DOI:10.12056/j.issn.1006-2785.2017.39.7.2016-2188
自体DC/CIK细胞免疫治疗对EGFR基因突变阴性的晚期肺腺癌患者外周血微转移指标的影响
DC/CIK immunotherapy for patients with advanced lung cancer with negative EGFR gene mutation
摘要
Abstract
Objective To evaluate the clinical effect of DC/CIK immunotherapy in treatment of advanced lung adenocarcinoma patients with negative epidermal growth factor receptor (EGFR) gene mutation.Methods One hundred and twenty advanced lung cancer patients with negative EGFR gene mutation were randomly divided into two groups with 60 cases in each group.Patients in treatment group received DC/ClK immunotherapy and those in control group were followed up only.Real-time PCR was used to examine the expression of CEA mRNA,MK mRNA and Lunx mRNA.Progression free survival (PFS) was used to monitor the change of clinical state after treatment with DC/CIK.And the results were analyzed statistically.Results The expression levels of CEA mRNA,MK mRNA and Lunx mRNA in treatment group were lower than those in control group 1 and 3 months after treatment (all P＜0.05).After 3 months,in control group there were 38 cases with CEA mRNA ＞108 copies/ml,32 cases with MK mRNA ＞ 109 copies/ml and 35 cases with Lunx mRNA ＞ 109 copies/ml.In treatment group there was significant difference in CEA mRNA and MK mRNA expression before and after DC/CIK treatment(all P＜0.05).The progression-free survival in treatment and control groups was 3.10 months and 2.52 months,respectively (P＜0.05).Conclusion DC/CIK immunotherapy can improve the quality of life and may be used as a maintenance treatment for patients with advanced lung adenocarcinoma.关键词
肺腺癌/DC/CIK/微转移指标/癌胚抗原mRNA/中期因子mRNA/肺癌特异性X蛋白mRNA/维持治疗Key words
Lung adenocarcinoma/Dendritic cells-cytokine-induced killer cells/Micrometastases/Carcinoembryonic antigen mRNA/Midkine mRNA/Lung specific X protein mRNA/Maintenance therapy引用本文复制引用
陆华东,马志红,刘志聪,邱国琴,华锋,崔恩海,王斌..自体DC/CIK细胞免疫治疗对EGFR基因突变阴性的晚期肺腺癌患者外周血微转移指标的影响[J].浙江医学,2017,39(7):501-504,4.基金项目
浙江省医药卫生平台计划(2015DTA016) （2015DTA016）
