浙江医学2017，Vol.39Issue(7)：508-511,4.DOI:10.12056/j.issn.1006-2785.2017.39.7.2016-1763
MMP-9基因-1562C/T变异与吸烟的交互作用对颈动脉易损斑块的影响
Interaction of MMP-9 gene-1562C/T mutation with smoking on susceptibility of instable carotid plaques
蒋健刚 1兰景良 1王晓华 1杜晓马1
作者信息
- 1. 321000金华,浙江中医药大学附属金华市中医院心内科
- 折叠
摘要
Abstract
Objective To investigate the relationship between polymorphism of MMP-9 gene-1562C/T and susceptibility of instable carotid plaques.Methods Total 358 patients with ultrasonic diagnosed-carotid plaques were enrolled in the study,including 122 cases with instable carotid plaques (instable group) and 236 cases with stable carotid plaques (stable group).The MMP-9 genotypes were detected by PCR-RFLP.Chi-square test was used to compare the distribution of the genotype and allele frequency between two groups.And the interaction of-1562c/r mutation with smoking on susceptibility of instability of carotid plaques was analyzed using additive model.Results The frequency of CT and TT genotypes in carotid instable group was significantly higher than that in the stable group (20.90％ vs.11.65％,x2=10.91,P＜0.01),and the frequency of smoking was also higher (x2=9.74,P＜0.01).The qualitative analysis of interaction showed that compared to non-smokers carrying CC genotype,the OR value of smoker was 1.56 (P＜0.05),the OR value of carrying T allele was 1.67 (P＜0.05) and that of smokers carrying T allele was 3.60 (P＜0.01),there was an additive interaction between smoking and T allele.Multiple logistic regression showed that after adjusting the gender,age,BMI,blood press,HbA1c and LDL-C,there was a positive interaction between T allele and smoking on instability of carotid plaques.The synergy index of 2.12,the attributable interaction index of.36;the attributable interaction percentage was 37.78％,and pure attributable interaction percentage was 52.30％.Conclusion There is a synergy between the-1562C/T mutation of MMP-9 gene and smoking on instability of carotid plaques.The study indicates that for smokers carrying the T allele to quit smoking may decrease the risk of instability of carotid plaques.关键词
颈动脉易损斑块/基因多态性/基质金属蛋白酶-9/吸烟/交互作用Key words
Carotid vulnerable plaque/Gene polymorphisms/Matrix metalloproteinase-9/Smoking/Interaction引用本文复制引用
蒋健刚,兰景良,王晓华,杜晓马..MMP-9基因-1562C/T变异与吸烟的交互作用对颈动脉易损斑块的影响[J].浙江医学,2017,39(7):508-511,4.
