浙江医学2017，Vol.39Issue(7)：559-561,3.DOI:10.12056/j.issn.1006-2785.2017.39.7.2016-843
肺表面活性物质联合双相呼吸道正压通气治疗新生儿呼吸窘迫综合征疗效观察
Clinical efficacy of pulmonary surfactant combined with biphasic positive airway pressure ventilation in treatment of neonatal respiratory distress syndrome
金伟敏 1杨秀录 2郑戈 1黄雨茅 1陈翔3
作者信息
- 1. 325200 温州医科大学附属第三医院儿科
- 2. 瑞安市妇幼保健院B超室
- 3. 温州医科大学附属育英儿童医院儿童康复医学科
- 折叠
摘要
Abstract
Objective To assess the clinical efficacy of pulmonary surfactant (PS) combined with biphasic positive airway pressure(BIPAP) in treatment of neonatal respiratory distress syndrome (NRDS).Methods Eighty six NRDS children treated with BIPAP were assigned to two groups:51 cases received additional administration of PS (study group) and 35 cases had no additional PS treatment (control group).The arterial oxygen tension (PaO2),oxygen index (PaO2/FiO2),pH value,arterial carbon dioxide tension(PaCO2),arterial oxygen and oxygen alveolar partial pressure ratio(PaO2/PAO2),mechanical ventilation parameters,duration of mechanical ventilation,length of hospital stay and the survival rate in two groups were compared.Results After treatment,the PaO2,pH,PaO2/FiO2 and PaO2/PAO2 in study group were higher than those in control group in all time points,and the PaCO2 was decreased (P＜0.05).The FiO2,MAP and PEEP in study group at all time points after treatment were significantly lower than those before treatment and control group (P＜0.05).The FiO2 and MAP in control group 24h and 48 h after treatment were lower,and PEEP was higher than those before treatment (both P＜0.05).The mechanical ventilation time in study group was significantly shorter than that in the control group (P＜0.05).The study group had significantly shorter time of oxygen therapy and shorter length of hospital stay than the control group (P＜0.01).The survival rate in study group was significantly higher than that of the control group (94.1％ vs 85.7％,P＜0.05).Conclusion The administration of pulmonary surfactant combined with biphasic positive airway pressure ventilation can effectively improve pulmonary function,shorten hospitalization time,reduce mortality and improve the prognosis in children with NRDS.关键词
肺表面活性物质/双相呼吸道正压通气/新生儿呼吸窘迫综合征Key words
Pulmonary Surfactant/Biphasic positive airway pressure ventilation/Neonatal Respiratory Distress SSyndrome引用本文复制引用
金伟敏,杨秀录,郑戈,黄雨茅,陈翔..肺表面活性物质联合双相呼吸道正压通气治疗新生儿呼吸窘迫综合征疗效观察[J].浙江医学,2017,39(7):559-561,3.
