浙江医学2017，Vol.39Issue(8)：614-616,627,4.DOI:10.12056/j.issn.1006-2785.2017.39.8.2017-140
630～650nm可见光对小鼠创面愈合的影响研究
630-650nm visible light promotes acute wound healing in mice
毛和水 1江文政 1王野平 1仇旭光1
作者信息
- 1. 321000 金华市中心医院烧伤整形皮肤外科
- 折叠
摘要
Abstract
Objective To investigate the effects of 630-650nm visible light on wound healing in mice.Methods The round full-thickness skin defects of 8mm diameter were symmetrically made in the back of 40 male C57BL/6 mice.The left side of the wound was exposed to 630-650nm visible lights immediately after modeling (study group) and the right side was treated with normal LED light (control group).The wound healing rate at different time points was observed and compared between two groups.The infiltrations of neutrophils (PMN) and macrophages (M φ) were detected by immunohistochemical staining;and the expression of TNF-a and IL-6 was detected with ELISA.Results The wound healing rate at 3d,7d and 12d after modeling in study group was significantly higher than that in control group (P＜0.05).The infiltration of PMN and M φ was lower in study group than that in control group at 24h and 3d after the modeling (P＜0.05).The protein expression of IL-6 and TNF-α was lower in study group than that in control group at 12h,24h,3d and 7d after the modeling (P＜0.05).Conclusion 630～650nm visible light can promote the healing of acute wounds in mice,which is associated with the decreased infiltration of inflammatory cells and inhibiting the secretion of inflammatory factors.关键词
630～650nm/可见光/弱激光治疗/创面愈合/炎症反应Key words
630～650nm/Visible light/LLLT/Wound healing/Inflammatory response引用本文复制引用
毛和水,江文政,王野平,仇旭光..630～650nm可见光对小鼠创面愈合的影响研究[J].浙江医学,2017,39(8):614-616,627,4.
