浙江医学2017，Vol.39Issue(8)：617-619,623,4.DOI:10.12056/j.issn.1006-2785.2017.39.8.2017-293
NSCLC中AEG-1的表达及与临床病理特征和血管生成的关系研究
Expression of AEG-1 in non-small cell lung cancer and its relation to clinicopathological features and angiogenesis
摘要
Abstract
Objective To investigate the expression of astrocyte elevated gene-1 (AEG-1) in non-small cell lung cancer (NSCLC) its relation to clinicopathological features and angiogenesis of tumor.Methods Expression of AEG-1,and intratumoral microvessel density (MVD,labeled by CD105) were assessed by immunohistochemistry in 92 NSCLC tissue specimens and corresponding adjacent normal tissue specimens.The relationship of AEG-1 with MVD and clinicopathological features of NSCLC was analyzed.Results The over-expression rate of AEG-1 NSCLC carcinoma tissue was 59.78％(55/92),which was significantly higher than that in adjacent normal tissue(7.61％,7/92)(P＜0.05).Upregulated expression of AEG-1 was significantly associated with clinical stage(P＜0.05),tumor differentiation(P＜0.05),lymph nodes metastasis(P＜0.05),and higher MVD (P ＜0.05) in patients with NSCLC.Conclusion The results suggest that AEG-1 may be involved in malignant transformation and tumor angiogenesis in NSCLC,and targeted inhibition of AEG-1 expression might be a novel strategy for treatment of NSCLC.关键词
AEG-1/非小细胞肺癌/血管生成/微血管密度/免疫组织化学Key words
Astrocyte elevated gene-1/Non-small cell lung cancer/Angiogenesis/Intratumoral microvessel density/Immunohistochemistry引用本文复制引用
马志红,陈莹蓉,董顺利,徐旭婷,刘进,宋鹏涛,李鸿伟,戴利成..NSCLC中AEG-1的表达及与临床病理特征和血管生成的关系研究[J].浙江医学,2017,39(8):617-619,623,4.基金项目
浙江省自然科学基金青年项目(LQ14H160015) （LQ14H160015）
湖州市公益性技术应用研究一般项目(2013GY17,2014GYB21) （2013GY17,2014GYB21）
