浙江医学2017，Vol.39Issue(8)：635-637,640,4.DOI:10.12056/j.issn.1006-2785.2017.39.8.2016-1408
肾小球内IgA沉积量对IgA肾病患者系膜病变的影响研究
Correlation of quantity of glomerular IgA deposition with severity of mesangial lesions in IgA nephropathy
叶林峰 1陈孝倩 1李凡凡 1黄朝兴1
作者信息
- 1. 325000 温州医科大学附属第一医院肾内科
- 折叠
摘要
Abstract
Objective To investigate the correlation between the quantity of IgA deposition in glomerulus and the severity of mesangial lesions in IgA nephropathy.Methods Seventy patients with primary IgA nephropathy (IgAN) were enrolled in the study,including 35 cases with mesangial lesions (group M1) and 35 cases without mesangial lesions (group M0).IgA was detected with immunohistochemical staining in renal tissue and analyzed with the ImagePro Plus (IPP) computer image analysis software.The IgA deposition parameters included the area of deposition (Area),density of deposition (Density mean),integral optical density of the deposition (IOD) and the ratio of IgA deposition area to the glomerular area (Per area).The IgA deposition parameters and clinical parameters were compared between two groups.Results There were no significant differences in gender,age,serum creatinine,uric acid,IgA,complement C3 and complement C4 levels,estimated glomerular filtration rate,and the incidence of low estimated glomerular filtration rate,hyperuricemia,high serum IgA level,low serum complement C3 and C4 levels between two groups.The proportion of patients of segmental sclerosis (S1) and glomerular endothelial cell hyperplasia (E1) in two groups also had no differences (P ＞0.05).Compared with group M0,group M1 had higher levels of 24-h urinary protein,and lower levels of serum albumin.Group M1 also had higher proportion of hypoalbuminemia and higher proportion of tubular atrophy or interstitial fibrosis(≥T1)(P＜0.05).The Area,Density mean,IOD and Per area levels in group M1were higher than those in group M0 (P＜0.05).Conclusion The severity of the IgAN mesangial lesions is correlated with the quantity of glomerular IgA deposition in patients with IgA nephropathy.关键词
IgA肾病/IgA沉积/系膜病变Key words
IgA nephropathy/Quantity of IgA deposition in glomerulus/Mesangial lesions引用本文复制引用
叶林峰,陈孝倩,李凡凡,黄朝兴..肾小球内IgA沉积量对IgA肾病患者系膜病变的影响研究[J].浙江医学,2017,39(8):635-637,640,4.
