安徽医科大学学报2017，Vol.52Issue(5)：687-691,5.DOI:10.19405/j.cnki.issn1000-1492.2017.05.014
西藏藏族人群和汉族人群载脂蛋白A5-1131T＞C多态性与机体脂肪含量的关系
Relationship between apolipoprotein A5gene-1131T＞C and fat content on adult Tibetans in Tibetarea and Han nationality population in Liaoning province
摘要
Abstract
Objective To explore the gene frequency of apolipoprotein A5(APOA5)-1131T>C single nucleotide polymorphisms and its relationship with the fat contents of adult Tibetans in Tibet and Han nationality population in Liaoning province.Methods In 100 Tibetan nationality(the study group) and 100 Han nationality individuals(the control group), the polymorphism of apoa5-1131T>C genotypes was detected by polymerase chain reaction-restricted fragments length polymorphism(PCR-RFLP), and fat contents were got by using bioelectrical impedance measurement.Results Results of fat contents of body, trunk and limbs(left upper limbs, left lower limbs, right upper limbs, right lower limbs and total limbs) were respectively below:① There was significant difference between male TC+CC genotype and TT genotype of Tibetan nationality.There was significant difference between male TT genotype of Tibetan nationality and of Han nationality.② There was significant difference between female TT genetype of Tibetan nationality and of Han nationality except result of the body fat contents.③ There was significant difference between the trunk and total limbs fat contents in male TT genotype, and male TC+CC genotype of Tibetan nationality and of Han nationality, and female TT genotype of Tibetan nationality.Conclusion APOA5 gene-1131T>C affects the body fat contents of Tibetans and Han nationality population, and APOA5 gene-1131T>C probably affects lipopexia in trunk.关键词
载脂蛋白A5-1131T＞C/单核苷酸多态性/脂肪含量/藏族/汉族Key words
APOA5 gene-1131T＞C/single nucleotide polymorphisms/fat content/Tibetan nationality/Han nationality分类
生物科学引用本文复制引用
刘海松,温有锋..西藏藏族人群和汉族人群载脂蛋白A5-1131T＞C多态性与机体脂肪含量的关系[J].安徽医科大学学报,2017,52(5):687-691,5.基金项目
国家自然科学基金资助项目(编号:31571233) （编号:31571233）
