安徽医科大学学报2017，Vol.52Issue(5)：756-761,6.DOI:10.19405/j.cnki.issn1000-1492.2017.05.030
成人原发性IgA肾病患者肾脏IgM沉积与临床及病理的关系
Relationship between renal IgM deposition and clinicopathologicalfeatures of adult patients with primary IgA nephropathy
摘要
Abstract
Objective To explore the relationship between renal IgM deposition and clinicopathological features of adult patients with primary IgA nephropathy (IgAN).Methods A total of 147 adult patients diagnosed to have primary IgAN by kidney biopsy were divided into two groups by renal IgM deposition: IgM negative group and IgM deposition group.The clinical manifestations, laboratory tests and renal pathological features of two groups were retrospectively investigated and compared.Results ① Compared to IgM negative group, IgM deposition group had a significantly increase in the number of patients with nephrotic syndrome, proteinuria in 24 h,urinary protein:creati-nine ratio in 24 h, urine total protein, blood urea nitrogen, urinary transferrin, urinary albumin, urinary IgG and urinary N-Acetyl-β-D-glucosaminidase (NAG) (P<0.05).Besides, IgM deposition group was found a significantly lower serum albumin, estimated glomerular filtration rate (eGFR), serum IgG and worse stages of chronic kidney disease (CKD) than IgM negative group.② The percentage of patients with Lee grading Ⅳ in IgM deposition group increased, but there was no significant difference between the two groups.In the Oxford classification of IgAN, no significant difference was found in the severity scores of M, E and S between the two groups while the IgM deposition group was found a higher severity scores of T than the IgM negative group (P<0.05).According to the Katafuchi semiquantitative critiria of IgAN, The difference in the total pathological score and tubulo-interstitial score between IgM negative group and IgM deposition group was significant (P<0.05).Conclusion Adult primary IgAN patients with renal IgM deposition are with greater urinary protein excretion, worse clinical manifestations, more obvious glomerular injury, worse renal tubulointerstitial lesions and renal pathological damage than those of IgM negative group.关键词
IgA肾病/IgM沉积/肾脏病理/Lee氏分级/牛津分类Key words
IgA nephropathy/IgM deposition/renal pathology/Lee grading/Oxford classification分类
医药卫生引用本文复制引用
汪燕,江肖,徐兴欣,卫洁,张炜..成人原发性IgA肾病患者肾脏IgM沉积与临床及病理的关系[J].安徽医科大学学报,2017,52(5):756-761,6.基金项目
国家自然科学基金(编号:81301660) （编号:81301660）
