高等学校化学学报2017，Vol.38Issue(5)：722-728,7.DOI:10.7503/cjcu20170003
酮洛芬/酸改性蒙脱土缓释体系的制备及体外释药研究
Preparation and in vitro Release of Ketoprofen/acid-montmorillonite
摘要
Abstract
With acid-montmorillonite(acid-MMT) as the carrier of ketoprofe(KPF), KPF/acid-MMT composite was prepared by ion-exchange method and characterized by powder XRD, BET, SEM, etc.The effect of the pH of release media on in vitro release of ketoprofen was assessed by the dialysis method.Three models for in vitro drug release were used to simulate the release performance of KPF from the KPF/acid-MMT composite.The results showed that the surface area of acid-MMT increased from 19.66 m2/g to 202.84 m2/g, and the drug-loading increased from 18.09% to 37.24% compared with MMT.In vitro release ability of KPF/acid-MMT composite was affected by pH of the release solution.In the artificial gastric juice(pH=1.2) and in the artificial intestinal juice(pH=6.8), the in vitro cumulative release amounts of the composites were 18.6% and 86.7%, respectively.The zero order kinetics model could be used to describe the variation of in vitro release rate.关键词
蒙脱土/酮洛芬/酸改性/pH响应/缓释载体Key words
Montmorillonite/Ketoprofen/Acid-treatment/pH-response/Sustained release carrier分类
化学化工引用本文复制引用
李婷婷,赵乐乐,王锐利,张淑秋..酮洛芬/酸改性蒙脱土缓释体系的制备及体外释药研究[J].高等学校化学学报,2017,38(5):722-728,7.基金项目
山西省青年科技研究基金(批准号:201601D202105)和山西医科大学博士启动基金(批准号:03201529)资助.Supported by the Natural Science Foundation of Shanxi Province,China(No.201601D202105) and the Foundation for PhD of Shanxi Medical University,China(No.03201529). （批准号:201601D202105）
