Gli1调控口腔鳞状细胞癌上皮-间充质转化的研究进展OACSTPCD
The research progress of Gli1 in the regulation of epithelial mesenchymal transition in oral squamous cell car-cinoma
HH(hedgehog)信号通路轴由:hedgehoge配体(Shh、Ihh和Dhh)、Patch和Smo两个膜蛋白形成复合物以及下游锌指核转录因子Gli组成,HH信号通路中锌指核转录因子Gli家族以Gli1为主导并起到决定性作用.上皮-间充质转化与包括口腔鳞状细胞癌在内的多种肿瘤的侵袭和转移密切相关,关于口腔鳞状细胞癌与Shh/Gli1信号轴的作用研究报道较少见,现就口腔鳞状细胞癌发生上皮-间充质转化与Gli1的相关性研究进展作一综述.
HH (hedgehog) signal pathway consists the hedgehoge ligand (Shh、Ihh and Dhh), the Patch and Smo membrane protein complex and Zinc finger transcription factor Gli (Gli1, Gli2, Gli3). In HH (hedgehog) signaling path-way, Gli1 not only plays a dominant and decisive role in the zinc finger transcription factor Gli (Glioma-associated onco-gene homolog) family, but also includes epithelial-mesenchymal transition (EMT) and oral squamous cell carcinoma, tu-mor…查看全部>>
张焕东
暨南大学医学院,广东广州 510632
医药卫生
Gli1上皮-间充质转化HH信号通路口腔鳞癌肿瘤转移抑制
Gli1Epithelial-mesenchymal transitionHedgehog signaling pathwayOral squamous cell carcino-maTumor metastasis suppressor
《口腔疾病防治》 2017 (5)
327-330,4
国家自然科学青年基金项目(81101652)广东省科技计划项目(2014A020212585)暨南大学科研与培养创新基金(21615418)
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