国际神经病学神经外科学杂志2017，Vol.44Issue(2)：145-150,6.DOI:10.16636/j.cnki.jinn.2017.02.007
药物难治性半球病变性癫痫手术治疗效果及手术方式比较的回顾性研究
Surgical outcome of medically intractable hemispheric epilepsy and clinical effect of functional hemispherectomy versus hemispherotomy: a retrospective analysis
摘要
Abstract
Objective To investigate the surgical outcome of medically intractable hemispheric epilepsy and the clinical effect of functional hemispherectomy (HF) versus hemispherotomy (H).Methods A retrospective analysis was performed for the clinical data of 25 patients with medically intractable hemispheric epilepsy who underwent surgical treatment in our department from 2005 to 2017.According to the surgical procedure,these patients were divided into FH group with 15 patients and H group with 10 patients.The time of operation,intraoperative blood loss,perioperative complications,postoperative epilepsy control,and neurological function were retrospectively analyzed.Results The postoperative follow-up lasted for 1-12 years,and the mean follow-up time was 5.28 ± 2.91 years.Two patients were lost to follow-up,and among the other patients,19 (82.60％) had an Engel Ⅰa outcome,3 (13.04％) had an Engel Ⅰd outcome,and 1 (4.36％) had an Engel Ⅱa outcome.There was no significant difference in the control rate of epilepsy between the FH group and the H group (P ＞ 0.05).Compared with the H group,the FH group had a significantly longer time of operation and significantly higher intraoperative blood loss (P ＜ 0.05).Conclusions FH is an effective surgical procedure for the treatment of medically intractable hemispheric epilepsy and allows for a high epilepsy-free rate after surgery,and some patients may achieve improvements in neurological function.Hemispherotomy is an effective minimally invasive surgical procedure and holds promise for clinical application.关键词
药物难治性癫痫/手术/疗效/神经功能Key words
Medically intractable epilepsy/Surgery/Clinical outcome/Neurological function引用本文复制引用
徐冰茹,谭婷,张正迪,李峥辉,姚一,高志莹,甘何霞,王圆庆,王逢鹏,陈田,陈蔚煊..药物难治性半球病变性癫痫手术治疗效果及手术方式比较的回顾性研究[J].国际神经病学神经外科学杂志,2017,44(2):145-150,6.基金项目
南京军区医学科技创新课题(ZD26) （ZD26）
