国际神经病学神经外科学杂志2017，Vol.44Issue(2)：171-175,5.DOI:10.16636/j.cnki.jinn.2017.02.012
创伤性颅脑伤后小鼠皮层和海马Wnt3a和β-Catenin的表达变化
Changes in expression of Wnt3a and β-catenin in the cortex and the hippocampus after traumatic brain injury in mice
摘要
Abstract
Objective To investigate the expression of Wnt3a and β-catenin in the cortex and the hippocampus after traumatic brain injury in mice and its clinical significance.Methods A mouse model of traumatic brain injury was established,and Western blotting and immunohistochemistry were used to measure the changes in the protein expression of Wnt3a and β-catenin after traumatic brain injury.Results The control group had low expression of Wnt3a and β-catenin in brain tissue.At 1 hour after traumatic brain injury,the content of β-catenin and Wnt3a in the cortex and the hippocampus started to increase.At 6 hours and 7 days after traumatic brain injury,the traumatic group had significant increases in the protein expression of β-catenin and Wnt3a (P ＜ 0.05).Immunofluorescent staining showed that at 24 hours after brain injury,there were increases in the expression of β-catenin and Wnt3a in the cortex and the hippocampus.Conclusions The protein expression of Wnt3a and β-catenin increases significantly in the early stage and recovery stage after traumatic brain injury,suggesting that Wnt3a and β-catenin may play important roles in the pathophysiological mechanism of traumatic brain injury.关键词
创伤性颅脑伤/Wnt3a/β-连环蛋白Key words
Traumatic brain injury/Wnt3a/β-catenin引用本文复制引用
李娟,饶维,吴颜艳,荔志云,马义辉..创伤性颅脑伤后小鼠皮层和海马Wnt3a和β-Catenin的表达变化[J].国际神经病学神经外科学杂志,2017,44(2):171-175,5.基金项目
国家自然科学青年科学基金项目81401020. （）
