广西医科大学学报2017，Vol.34Issue(5)：702-705,4.DOI:10.16190/j.cnki.45-1211/r.2017.05.016
局灶性脑梗死后豆状核继发性损害的磁共振弥散张量研究
The secondary degeneration of lentiform nucleus following focal cerebral infarct detected by diffusion tension imaging
摘要
Abstract
Objective:To observe the dynamic process of the secondary degeneration in lentiform nucleus following a focal corona radiate infarct with diffusion tensor imaging (DTI),and explore the relationship be tween the secondary degeneration and the time course of patients' rehabilitation.Methods:18 patients with an acute infarct at unilateral corona radiata were selected and defined as a study group.And 18 healthy age-and gender-matched volunteers were enrolled as a control group.The degree of nervous functional defects,motor function and activity of daily living were assessed by National Institutes of Health Stroke Scale (NIHSS) scores,Fugl-Meyer assessment and Barthel index (BI),respectively.Unified Parkinson's disease rating scale (UPDRS) was used to evaluate the Parkinson-like symptoms.Results:From the first week (W1) to the 12th week (W12),the mean diffusivity (MD) of lentiform nuclear in ipsilateral side was gradually increased (P ＜ 0.01),while the anisotropy (FA) showed no significant change (P ＞0.05).MD and FA values in contralateral side of lentiform nucleus also had no obvious change (P ＞0.05).The increased percentage of MD in ipsilateral side of lentiform nucleus was negatively related to the reduced percentage of NIHSS score (r =-0.694,P ＜0.01),and was positively correlated to the increased percentage of BI (r =0.662,P ＜ 0.05),but was not related to the increased percentage of FM (r =0.489,P ＞0.05).Compared with the 3 patients without Parkinson-like symptoms,MD value of lentiform nucleus in ipsilateral side was increased (P ＜0.05).And MD value was positively correlated to the scores of UPDRS (r =0.486,P ＜0.05).Conclusion:A focal corona radiate infarct may cause secondary degeneration in ipsilateral side of lentiform neuleus,and gradually worsened.The secondary degeneration may hinder the restoration of neural function and participate in the process of vascular Parkinson's syndrome.关键词
脑梗死/豆状核/继发性损害/弥散张量成像Key words
cerebral infarct/lentiform nucleus/secondary degeneration/diffusion tensor imaging分类
医药卫生引用本文复制引用
林宝全,石胜良,秦超,王子军,李宗亚,梁志坚..局灶性脑梗死后豆状核继发性损害的磁共振弥散张量研究[J].广西医科大学学报,2017,34(5):702-705,4.基金项目
国家自然科学基金资助项目(No.30860088 （）
No.81260186) （）
广西自然科学基金资助项目(No.0832134 （）
No.0991149 （）
No.2015jjAA40373) （）
