广西医科大学学报2017，Vol.34Issue(5)：706-709,4.DOI:10.16190/j.cnki.45-1211/r.2017.05.017
319例儿童手足口病病原学分析
Etiologicalanalysis of 319 cases of hand foot and mouth disease
摘要
Abstract
Objective:To investigate the etiological characteristics of 319 cases of hand foot mouth disease (HFMD).Methods:A total of 319 children diagnosed with HFMD from January 2014 to January 2016 in Guangxi were collected and divided into three groups:fatal group (85 9ases),severe group (132 cases) and mild group (102 cases).Serum EV71-IgM antibody and CVA16-IgM antibody were detected with enzymelinked immunosorbent assay (ELISA).Results:The positive rate of EV71-IgM antibody in the fatal group and severe group were significantly higher than that in the mild group (P ＜0.05).The positive rate of EV71-IgM antibody in death cases was 85.71 ％.The positive rate of CVA16-IgM antibody in mild group was significantly higher than those in the fatal group and severe group (P ＜0.05).There was no significant difference on the gender ratio and age composition among EV71-IgM antibody positive cases,CVA16-IgM antibody positive cases,EV71-IgM antibody and CVA16-IgM antibody double positive cases,EV71-IgM antibody and CVA16-IgM antibody double negative cases (P ＞0.05).Conclusion:The etiology analysis revealed that severe and fatal HFMD were mainly caused by EV71.Meanwhile,we need to pay attention to the possibility that CVA16 and other enteroviruses infected cases developing into severe ones.关键词
手足口病/病原学/肠道病毒71型/柯萨奇病毒A组16型Key words
hand foot and mouth disease/etiology/enterovirus 71/coxsackievirus A16分类
医药卫生引用本文复制引用
林威,李燕,陆富策,陈经纶,农光民..319例儿童手足口病病原学分析[J].广西医科大学学报,2017,34(5):706-709,4.基金项目
国家自然科学基金资助项目(No.81460251) （No.81460251）
广西壮族自治区手足口病防治研究基金资助项目(No.2014249) （No.2014249）
