广西医科大学学报2017，Vol.34Issue(5)：714-717,4.DOI:10.16190/j.cnki.45-1211/r.2017.05.019
结缔组织病合并肺血栓栓塞17例临床特征分析
A retrospective analysis of 17 cases of connective tissue disease complicated with pulmonary thromboembolism
摘要
Abstract
Objective:To analyze the clinical features and treatment of 17 cases of connective tissue disease (CTD) complicated with pulmonary thromboembolism (PTE).Methods:The clinical data of 17 patients with CTD and PTE treated in our hospital from 2006 to 2015 were retrospectively analyzed.Results:Of 17 cases,7 were male and 10 were female.The age ranged from 15 to 72 years with an average age of (40±16) years.There were 12 cases of low-risk,3 cases of intermediate risk and 2 cases of high-risk according to PTE risk degree.9 cases were diagnosed as systemic lupus erythematosus,2 cases were systemic vasculitis,2 cases were Behcet's syndrome,1 case was undifferentiated connective tissue disease,1 case was dermatomyositis,1 case was anti J0-1 antibody syndrome and 1 case was antiphospholipid syndrome.The main symptoms were dyspnea,chest pain,hemoptysis,cough and fever.The arterial oxygen partial pressure (PaO2) was lower than 10.6 kPa in 5 cases.Positive autoantibody was found in 13 cases,and the elevated erythrocyte sedimentation rate (ESR) in 14 cases and elevated C-reactive protein in 11 cases.The Ddimer level in 17 cases were 167μg/L to 4,173 μg/L.13 cases were complicated with pulmonary parenchyma or interstitial lesion,and 2 cases of pulmonary artery aneurysm.And some of them had inferior vena cava,portal vein thrombosis.16 cases were treated with glucocorticoid and immunosuppressive agents combined with thrombolytic therapy.The anticoagulant period ranged from 4 months to 23 months.Conclusion:As one of the risk factors for pulmonary embolism,CTD was easy to miss diagnose or misdiagnose in PTE patients.Paying attention to the treatment of CTD could promote the recovery of PTE and reduce recurrence.关键词
结缔组织病/肺血栓栓塞/临床特征Key words
connective tissue disease/pulmonary thromboembolism/clinical features分类
医药卫生引用本文复制引用
许海光,张建全,张慧,唐艳萍..结缔组织病合并肺血栓栓塞17例临床特征分析[J].广西医科大学学报,2017,34(5):714-717,4.基金项目
国家自然科学基金资助项目(No.81460009) （No.81460009）
