广西医科大学学报2017，Vol.34Issue(5)：727-729,3.DOI:10.16190/j.cnki.45-1211/r.2017.05.023
免疫抑制治疗成人非重型再生障碍性贫血的疗效及预后分析
Clinical efficacy of immunosuppression therapy on non-severe aplastic anamia adult patients
摘要
Abstract
Objective:To explore the clinical efficacy of immunosuppression therapy (IST) on non-severe aplastic anamia (NSAA) adult patients.Methods:51 adult patients with NSAA treated in our hospital from September 2006 to September 2013 were selected and divided into the immunosuppressive therapy (IST) group (n =37) and non-IST group (n =14).The response rate and 5-year survival rate were compared between the two groups.The factors influencing the 5-year survival rate were analyzed by univariate analysis and multiple logistic regression analysis.Results:The total response rate and 5-year survival rate in the IST group were 70.3％ and 76.1％ respectively,which were significantly higher than those in the non-IST group (14.3％ and 37.9％) (P ＜0.05).In IST group,the 5-year survival rate was 81.2％ after over one-year treatment,and was 66.8％ after ≤1 year treatment (P ＜0.05).The 5-year survival rates were 33.3％ and 73.5％ respectively in patients with hepatitis and without (P ＜0.05).Multiple logistic regression analysis showed that the IST was a protective factor for the prognosis of NSAA patients (P ＜0.05).Conclusion:IST was effective in the treatment of NSAA,and patients with over one year treatment had better prognosis.关键词
成人非重型再生障碍性贫血/疗效/预后/影响因素Key words
non-severe aplastic anemia in adults/curative effect/prognosis/influence factors分类
医药卫生引用本文复制引用
赵卫华,符美华,姚奕斌,姜彦枫,马劼..免疫抑制治疗成人非重型再生障碍性贫血的疗效及预后分析[J].广西医科大学学报,2017,34(5):727-729,3.基金项目
广西自然科学基金资助项目(No.2011GXNSFA018256) （No.2011GXNSFA018256）
广西医疗卫生适宜技术研究与开发项目(No.s201303-04) （No.s201303-04）
广西卫生和计划生育委员会自筹课题基金资助项目(No.Z2015565) （No.Z2015565）
广西医疗卫生适宜技术开发与推广项目(No.s201658) （No.s201658）
