广西医科大学学报2017，Vol.34Issue(5)：762-764,3.DOI:10.16190/j.cnki.45-1211/r.2017.05.034
儿童急性淋巴细胞白血病诱导化疗期合并脓毒症31例回顾分析
Children withacute lymphoblastic leukemia complicated with sepsisduring induction chemotherapy : retrospective analysis of 31 cases
凌纯 1陆美荣 2焦蓓蕾 2韦红英2
作者信息
- 1. 广西医科大学第九附属医院儿科,北海536000
- 2. 广西医科大学第一附属医院儿科,南宁530021
- 折叠
摘要
Abstract
Objective:To investigate the pathogenesis and therapeutic methods of acute lymphoblastic leukemia (ALL) complicated with sepsis in children during induction chemotherapy.Methods:The clinical data from31 cases of ALL complicated with sepsis children during induction chemotherapy from January 2013 to November 2014in our hospital were retrospectively analyzed.Results:31 cases of 126 ALL children were appeared sepsis (24.60％)with a cure rate of 90.32％ and mortality of 9.68％.Respiratory tract infection was the most common infection in clinic.Gram-negative bacilli were the main pathogenic bacteria.The drug susceptibility rate of the gram-negative bacteria to imipenem was 100 ％.The percentages of neutropenia and elevated C-reactive protein (CRP) in sepsis children were both 87.10％.The neutrophil counts in severe sepsis and septic shock children were significantly lower than those in non-severe ones(P ＜0.05).Conclusion:The ALLchildren during induction chemotherapywere susceptible to sepsis.Respiratory tract was the common primary infection site.Agranulocytosis after chemotherapy was a key factor for sepsis and could be a predictive marker for the severityof sepsis.关键词
急性淋巴细胞白血病/诱导化疗/脓毒症Key words
acute lymphoblastic leukemia/induction chemotherapy/sepsis分类
医药卫生引用本文复制引用
凌纯,陆美荣,焦蓓蕾,韦红英..儿童急性淋巴细胞白血病诱导化疗期合并脓毒症31例回顾分析[J].广西医科大学学报,2017,34(5):762-764,3.
