河北医学2017，Vol.23Issue(5)：712-716,5.DOI:10.3969/j.issn.1006-6233.2017.05.003
艾司西酞普兰对抑郁症患者各脑区5-HT DAINH NE表达的影响研究
The Effect of Escitalopram on the Expression of 5-HT DA INH and NE in Different Brain Regions of Patients with Depression
摘要
Abstract
Objective:To investigate the expression of 5-HT, DA, INH and NE in patients with depression after escitalopram treatment, and to provide the basis for clinical application.Methods: 50 cases of patients with depression admitted from June 2014 to January 2015 in our hospital were analyzed, using escitalopram to intervene;analysed live full brain, around the central, frontal, occipital, left and right around the left and right top, left temporal and other areas of the brain in 5-HT, DA, INH, NE induced analysis before and after treatment, patients with clinical treatment records.Results: The clinical effective rate was 92% after treatment with escitalopram;the 5-HT of the whole brain, right, right, right and right anterior temporal regions were significantly reduced, after treatment and the difference was statistically significant (P<0.05);The DA levels in the whole brain, right frontal, right central, right top, right anterior temporal area were significantly increased, and the difference was statistically significant (P<0.05);The INH level in the left frontal area was significantly lower (P<0.05);The left central part and right central NE levels were significantly lower (P<0.05);and the NE levels in the left and right occipital regions were significantly higher (P<0.05).Conclusion: After the treatment with escitalopram, the clinical effect of the patients with depression is good, and it can effectively correct the abnormal expression of 5-HT, DA, NE, and INH in each brain region.关键词
艾司西酞普兰/抑郁症/脑区/神经递质Key words
Escitalopram/Depression/Brain region/Neurotransmitter引用本文复制引用
万姝..艾司西酞普兰对抑郁症患者各脑区5-HT DAINH NE表达的影响研究[J].河北医学,2017,23(5):712-716,5.基金项目
四川省科技厅资助项目,(编号:2015011028) （编号:2015011028）
