中医学报2017，Vol.32Issue(5)：835-837,3.DOI:10.16368/j.issn.1674-8999.2017.05.218
中西医结合治疗一氧化碳中毒所致迟发性脑病临床研究
Clinical Study on Treatment of Delayed Encephalopathy Caused by Carbon Monoxide Poisoning with Integrative Medicine
摘要
Abstract
Objective:To observe the clinical effect of traditional Chinese medicine decoction combined with naloxone in treatment of delayed encephalopathy caused by carbon monoxide poisoning.Methods:300 patients were randomly divided into three groups:traditional Chinese medicine group,western medicine group and combination group,with 100 cases in each group.Chinese medicine group:①Using hyperbaric oxygen therapy;②Applying Chinese medicine decoction treatment.TCM Drug composition:Codonopsis 15 g,Angelica 10 g,Astragalus 30 g,Schisandra 10 g,Chinese wolfberry 15 g,Polygonum 25 g.According to TCM theory,add Radix scutellariae 12 g,Bile arisaema 12 g for patients with Phlegm and Fire Desturbing Heart Syndrome;add Poria 15 g,Bighead atractylodes rhizome12 g,Bile arisaema 12 g for patients with Spleen Deficiency and Phlegm Syndrome;add Flos carthami 9 g,Radix paeoniae rubra 9 g for patients with Blood Stasis and Qi Stagnation Syndrome;add Wolfberry12 g,Eucommia ulmoides olive 12 g,Achyranthes bidentata 12 g for patients with Spleen and Kidney Deficiency.One dose for twice taking each day.Western medicine group:①Treated with hyperbaric oxygen;②Treated with naloxone,3 times a day,with 8 mg in the mass fraction of 5％ glucose or saline,intravenous infusion.Combination group:① Treated with hyperbaric oxygen;② Treatment with traditional Chinese medicine decoction;③ Treated with naloxone.Hastigawa dementia scale (HDS) was used to detect the changes of intelligence before and after treatment and P300 latency was used as the criteria for clinical efficacy.Results:These 300 patients all completed the treatment.The clinical efficacy of the combination group was better than that of the traditional Chinese medicine group and the western medicine group (x2 =46.892,P ＜ 0.001),with significantly higher score of the Hasegawa dementia scale (P ＜ 0.05) and the significantly shorter latency (P ＜ 0.05).Conclusion:Traditional Chinese medicine decoction combined with naloxone in treatment of delayed encephalopathy caused by carbon monoxide poisoning has a significant clinical effect.关键词
一氧化碳中毒/迟发性脑病/纳洛酮/中西医结合Key words
carbon monoxide poisoning/delayed encephalopathy/naloxone/Integrative medicine分类
医药卫生引用本文复制引用
刘玉红..中西医结合治疗一氧化碳中毒所致迟发性脑病临床研究[J].中医学报,2017,32(5):835-837,3.基金项目
河北省中医药管理局科研计划项目(2015090) （2015090）
