华西口腔医学杂志2017，Vol.35Issue(3)：286-290,5.DOI:10.7518/hxkq.2017.03.011
复发性阿弗他溃疡患者可溶性程序性死亡受体1及可溶性程序性死亡配体1表达与免疫功能的相关性
Soluble programmed death-1 and soluble programmed death ligand 1 protein expression and immune status in patients with recurrent aphthous ulcer
摘要
Abstract
ObjectiveThis study aims to investigate the possible role and significance of soluble programmed death-1 (sPD-1) /soluble programmed death ligand 1 (sPD-L1) in the immune pathogeneses of recurrent aphthous ulcer (RAU).Methods A total of 30 RAU cases (18 cases of minor RAU, 5 cases of major RAU, and 7 cases of herpetiform ulcers) were enrolled in this study. A total of 18 healthy people served as controls. Lymphocyte subsets (CD3+, CD4+, CD8+, CD19+, and CD16++56+) were investigated by flow cytometric analysis. Humoral immunity (IgG, IgA, IgM, C3, and C4) was explored by nephelometry immunoassay. The sPD-1 and sPD-L1 protein levels in the sera of RAU patients were investigated by enzyme-linked immu-nosorbent assay. The correlations of the sPD-1 and sPD-L1 protein levels with the immune status and clinical characteristics of the RAU patients were analyzed by SPSS 19.0.Results The number of CD4+T cells decreased and the levels of IgM antibodies increased in the RAU patients relative to those in the normal controls (P<0.05). The sPD-1 and sPD-L1 protein levels in the RAU patients were significantly higher than those in the control group (P<0.05). Meanwhile, the sPD-1 and sPD-L1 protein levels in the patients with minor and major RAU were significantly higher than those in the control group r2=0.382,P2=0.037).Conclusion Cellular immune hypofunction and humoral immunity disorders were found in the RAU patients. The PD-1/PD-L1 signaling pathway, which might be influenced by the involvement of sPD-1 and sPD-L1 proteins to a certain extent, may play some roles in the immune pathogenesis of RAU.关键词
复发性阿弗他溃疡/可溶性程序性死亡受体1/可溶性程序性死亡配体1/免疫Key words
recurrent aphthous ulcer/soluble programmed death-1/soluble programmed death ligand 1/immune分类
医药卫生引用本文复制引用
江南,罗亮,刘莉,孙小琴,姜星,蔡扬..复发性阿弗他溃疡患者可溶性程序性死亡受体1及可溶性程序性死亡配体1表达与免疫功能的相关性[J].华西口腔医学杂志,2017,35(3):286-290,5.基金项目
国家自然科学基金(81460104) （81460104）
