华西口腔医学杂志2017，Vol.35Issue(3)：311-316,6.DOI:10.7518/hxkq.2017.03.015
CD44和CD133在口腔潜在恶性病变和口腔鳞状细胞癌中的表达及其临床意义
Clinical significance of CD44 and CD133 expression in oral potentially malignantdisorder and oral squamous cell carcinoma
摘要
Abstract
ObjectiveThis study aims to investigate the expression and relationship of CD44 and CD133 in normal oral mucosa, oral potentially malignant disorder (OPMD), and oral squamous cell carcinoma (OSCC). This work also analyzes the relationship between such expression and clinical factors. This study intends to evaluate the clinical value of using CD44 and CD133 as indices to evaluate the carcinogenic potential of OPMD.Methods Clinical data from 60 patients with OPMD, 60 patients with OSCC, and 10 cases of normal oral mucosa were analyzed. Double immunohistochemical analysis was applied to investigate the expression of CD44 and CD133 in paraffin sections of normal oral mucosa, OPMD, and OSCC tissues. Subsequently, the relationships between such expression and clinical factors were analyzed.Results The positive rates of CD44 expression in the normal oral mucosa, OPMD, and OSCC tissues were 100.00%, 96.67%, and 71.67% (P<0.05), res-pectively. Meanwhile, the positive rates of CD133 expression in the normal oral mucosa, OPMD, and OSCC tissues were 0.00%, 35.00%, and 63.33% (P<0.05), respectively. The expression of CD44 and CD133 was found to be correlated (P<0.05). Such expression was related to the clinical stages and lymphatic metastasis of OSCC (P<0.05).Conclusion CD44 and CD133 can be used individually as clinical indices to evaluate the carcinogenic potential of OPMD.关键词
CD44/CD133/口腔潜在恶性病变/口腔鳞状细胞癌/临床意义Key words
CD44/CD133/oral potentially malignant disorder/oral squamous cell carcinoma/clinical significance分类
医药卫生引用本文复制引用
祁佳佳,孙艳,袁昌青,姜文静,赵涵,曹远盼,刘秋艳..CD44和CD133在口腔潜在恶性病变和口腔鳞状细胞癌中的表达及其临床意义[J].华西口腔医学杂志,2017,35(3):311-316,6.基金项目
山东省研究生教育创新计划(SDYY11184) （SDYY11184）
