华西口腔医学杂志2017，Vol.35Issue(3)：334-338,5.DOI:10.7518/hxkq.2017.03.019
慢性牙周炎中肿瘤坏死因子α对骨髓间充质干细胞成骨分化的调控作用
Tumor necrosis factor-α regulates the osteogenic differentiation of bone marrow mesenchymal stem cells in chronic periodontitis
摘要
Abstract
Bone marrow mesenchymal stem cells (BMSCs) and ideal adult stem cells for alveolar bone regeneration consi-derably help restore the structure and function of the periodontium and promote the healing of periodontal disease. Thus, BMSC features, especially the mechanism of osteogenic differentiation, has recently become a research hotspot. Tumor necrosis factor-α(TNF-α), which is the main factor in the periodontal inflammatory microenvironment, is directly related to the osteogenic differentiation of BMSCs. Exploring the TNF-α-regulated differentiation mechanism of BMSCs aids in the search for new treatment targets. Such investigation also promotes the development of stem cell therapy for periodontal diseases. This article aims to describe the potential of TNF-α in regulating the osteogenic differentiation of stem cells.关键词
慢性牙周炎/肿瘤坏死因子α/骨髓间充质干细胞/成骨分化Key words
chronic periodontitis/tumor necrosis factor-α/bone marrow mesenchymal stem cells/osteogenic diffe-rentiation分类
生物科学引用本文复制引用
李晓光,王一珠,郭斌..慢性牙周炎中肿瘤坏死因子α对骨髓间充质干细胞成骨分化的调控作用[J].华西口腔医学杂志,2017,35(3):334-338,5.基金项目
国家自然科学基金面上项目(81470754) （81470754）
