中国健康心理学杂志2017，Vol.25Issue(6)：835-838,4.DOI:10.13342/j.cnki.cjhp.2017.06.010
安非他酮治疗卒中后抑郁的临床疗效及其对脑源性神经营养因子的影响
Effect of Bupropion on Depression after Post-stroke and Brain Deriven Neurotrophic Factor
摘要
Abstract
Objective:To investigate the effect of bupropion on post-stroke depression and the brain deriven neu-rotrophic factor(BDNF).Methods:A total of 60 patients with post-stroke depression were treated with bupropion. The period of study was 8 weeks.HAMD,TESS and BDNF were used to assess the efficacy and side effects before and 2 weeks,6 weeks and 8 weeks after the treatment.Results:Total scores of HAMD and HAMA decreased signifi-cantly at the end of the 2nd,4th,6th and 8th week(F =1501.920,P <0.001).BDNF scores from 2 weeks to 8 weeks increased dramatically as compared to pretreatment(F =1558.802,P <0.001).Conclusion:Bupropion in treating pa-tients with post-stroke depression has good anti-depressant.The degree of depression is negatively related to the level of BDNF.关键词
安非他酮/卒中后抑郁/脑源性神经营养因子/副反应量表Key words
Bupropion/Post-stroke depression/BDNF/TESS分类
医药卫生引用本文复制引用
徐倩,安宏伟,韩真贤,赵希武,孙大伟,李淑华,王锐成..安非他酮治疗卒中后抑郁的临床疗效及其对脑源性神经营养因子的影响[J].中国健康心理学杂志,2017,25(6):835-838,4.基金项目
黑龙江省大庆市指导性科技计划项目(编号:S2d-2015-72) （编号:S2d-2015-72）
