解放军医学院学报2017，Vol.38Issue(5)：399-401,3.DOI:10.3969/j.issn.2095-5227.2017.05.003
CUE结构域2表达与结直肠癌淋巴结转移的关系探讨
Relationship between the expression of CUE domain-containing 2 and lymph nodes metastasis in colorectal cancer
摘要
Abstract
Objective To analyze the relationship between the expression of CUE domain-containing 2 (CUEDC2) and lymph nodes metastasis in colorectal cancer. Methods Clinical data and paraffin sections of 153 patients with colorectal cancer who underwent operation in Chinese PLA General Hospital from December 2015 to May 2016 were collected. The expression of CUEDC2 was analyzed by immunohistochemistry assay and univariate and multivariate analyses were carried out to investigate the association of the expression of CUEDC2 with lymph nodes metastasis. Results The immunohistochemical score of CUEDC2 in cases with lymph nodes metastasis of colorectal cancer was significantly higher than those without metastasis (7.41±1.46 vs 4.61±1.27, P < 0.05). Multivariate logistic regression analysis revealed that high immunohistochemical score of CUEDC2 was independent riskfactor for lymph nodes metastasis in CRC patients (OR: 4.777, 95% CI : 2.827-8.071, P < 0.05). Conclusion High CUEDC2 immunohistochemical score ( ≥ 8) is correlated with lymph nodes metastasis in colorectal cancer and CUEDC2 probably promotes the metastasis.关键词
CUE结构域2/结直肠癌/淋巴结转移Key words
CUE domain-containing 2/colorectal cancer/lymph nodes metastasis分类
医药卫生引用本文复制引用
胡时栋,杨宇,王玉锋,杜晓辉,胡子龙,邹贵军,吴有军,邢晓伟,李宇轩,张凯,何长征,王迪..CUE结构域2表达与结直肠癌淋巴结转移的关系探讨[J].解放军医学院学报,2017,38(5):399-401,3.基金项目
国家自然科学基金项目(61471397) Supported by the National Natural Science Foundation of China (61471397) （61471397）
